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http://dx.doi.org/10.18419/opus-13499
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DC Element | Wert | Sprache |
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dc.contributor.author | Navas-Carretero, Santiago | - |
dc.contributor.author | San-Cristobal, Rodrigo | - |
dc.contributor.author | Siig Vestentoft, Pia | - |
dc.contributor.author | Brand-Miller, Jennie C. | - |
dc.contributor.author | Jalo, Elli | - |
dc.contributor.author | Westerterp-Plantenga, Margriet | - |
dc.contributor.author | Simpson, Elizabeth J. | - |
dc.contributor.author | Handjieva-Darlenska, Teodora | - |
dc.contributor.author | Stratton, Gareth | - |
dc.contributor.author | Huttunen-Lenz, Maija | - |
dc.contributor.author | Lam, Tony | - |
dc.contributor.author | Muirhead, Roslyn | - |
dc.contributor.author | Poppitt, Sally | - |
dc.contributor.author | Pietiläinen, Kirsi H. | - |
dc.contributor.author | Adam, Tanja | - |
dc.contributor.author | Taylor, Moira A. | - |
dc.contributor.author | Handjiev, Svetoslav | - |
dc.contributor.author | McNarry, Melitta A. | - |
dc.contributor.author | Hansen, Sylvia | - |
dc.contributor.author | Brodie, Shannon | - |
dc.contributor.author | Silvestre, Marta P. | - |
dc.contributor.author | Macdonald, Ian A. | - |
dc.contributor.author | Boyadjieva, Nadka | - |
dc.contributor.author | Mackintosh, Kelly A. | - |
dc.contributor.author | Schlicht, Wolfgang | - |
dc.contributor.author | Liu, Amy | - |
dc.contributor.author | Larsen, Thomas M. | - |
dc.contributor.author | Fogelholm, Mikael | - |
dc.contributor.author | Raben, Anne | - |
dc.contributor.author | Martinez, J. Alfredo | - |
dc.date.accessioned | 2023-09-13T12:11:50Z | - |
dc.date.available | 2023-09-13T12:11:50Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2296-861X | - |
dc.identifier.other | 1866252429 | - |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-135180 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/13518 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-13499 | - |
dc.description.abstract | Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. | en |
dc.description.sponsorship | EU framework program 7 (FP7/2007-2013) | de |
dc.language.iso | en | de |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/312057 | de |
dc.relation.uri | doi:10.3389/fnut.2021.733697 | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | de |
dc.subject.ddc | 570 | de |
dc.subject.ddc | 610 | de |
dc.title | Appraisal of triglyceride-related markers as early predictors of metabolic outcomes in the PREVIEW lifestyle intervention : a controlled post-hoc trial | en |
dc.type | article | de |
dc.date.updated | 2021-11-15T17:42:19Z | - |
ubs.fakultaet | Wirtschafts- und Sozialwissenschaften | de |
ubs.fakultaet | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.institut | Institut für Sport- und Bewegungswissenschaft | de |
ubs.institut | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.publikation.seiten | 12 | de |
ubs.publikation.source | Frontiers in nutrition 8 (2021), No. 733697 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 10 Fakultät Wirtschafts- und Sozialwissenschaften |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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fnut-08-733697.pdf | Artikel | 3,53 MB | Adobe PDF | Öffnen/Anzeigen |
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