Stereoselective synthesis of amino acid derivatives using carbohydrates as templates

Abstract

Glycosylamines contain the easily cleavable semi-aminal-type N-glycosidic bond. O-Protected glycosylamines, therefore, can advantageously be used as a form of "asymmetric ammonia", for instance, in Strecker syntheses and in Ugi reactions to give amino acid amides as well as in modifications of the Mannich reaction.