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http://dx.doi.org/10.18419/opus-11283
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Rebers, Lisa | - |
dc.contributor.author | Reichsöllner, Raffael | - |
dc.contributor.author | Regett, Sophia | - |
dc.contributor.author | Tovar, Günter E. M. | - |
dc.contributor.author | Borchers, Kirsten | - |
dc.contributor.author | Baudis, Stefan | - |
dc.contributor.author | Southan, Alexander | - |
dc.date.accessioned | 2021-02-10T15:06:13Z | - |
dc.date.available | 2021-02-10T15:06:13Z | - |
dc.date.issued | 2021 | de |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | 1748023004 | - |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-113000 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/11300 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-11283 | - |
dc.description.abstract | Gelatin methacryloyl (GM) hydrogels have been investigated for almost 20 years, especially for biomedical applications. Recently, strengthening effects of a sequential cross-linking procedure, whereby GM hydrogel precursor solutions are cooled before chemical cross-linking, were reported. It was hypothesized that physical and enhanced chemical cross-linking of the GM hydrogels contribute to the observed strengthening effects. However, a detailed investigation is missing so far. In this contribution, we aimed to reveal the impact of physical and chemical cross-linking on strengthening of sequentially cross-linked GM and gelatin methacryloyl acetyl (GMA) hydrogels. We investigated physical and chemical cross-linking of three different GM(A) derivatives (GM10, GM2A8 and GM2), which provided systematically varied ratios of side-group modifications. GM10 contained the highest methacryloylation degree (DM), reducing its ability to cross-link physically. GM2 had the lowest DM and showed physical cross-linking. The total modification degree, determining the physical cross-linking ability, of GM2A8 was comparable to that of GM10, but the chemical cross-linking ability was comparable to GM2. At first, we measured the double bond conversion (DBC) kinetics during chemical GM(A) cross-linking quantitatively in real-time via near infrared spectroscopy-photorheology and showed that the DBC decreased due to sequential cross-linking. Furthermore, results of circular dichroism spectroscopy and differential scanning calorimetry indicated gelation and conformation changes, which increased storage moduli of all GM(A) hydrogels due to sequential cross-linking. The data suggested that the total cross-link density determines hydrogel stiffness, regardless of the physical or chemical nature of the cross-links. | en |
dc.language.iso | en | de |
dc.relation.uri | doi:10.1038/s41598-021-82393-z | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.subject.ddc | 500 | de |
dc.subject.ddc | 540 | de |
dc.title | Differentiation of physical and chemical cross-linking in gelatin methacryloyl hydrogels | en |
dc.type | article | de |
ubs.fakultaet | Energie-, Verfahrens- und Biotechnik | de |
ubs.fakultaet | Externe wissenschaftliche Einrichtungen | de |
ubs.fakultaet | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.institut | Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie | de |
ubs.institut | Fraunhofer Institut für Grenzflächen- und Bioverfahrenstechnik (IGB) | de |
ubs.institut | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.publikation.source | Scientific reports 11 (2021), No. 3256 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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rebers_2021.pdf | Article | 2,37 MB | Adobe PDF | Öffnen/Anzeigen |
rebers_2021_support.pdf | Supplementary information | 431,51 kB | Adobe PDF | Öffnen/Anzeigen |
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