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dc.contributor.authorSchneider, Lucas-
dc.contributor.authorHerkt, Stefanie-
dc.contributor.authorWang, Lei-
dc.contributor.authorFeld, Christine-
dc.contributor.authorWesely, Josephine-
dc.contributor.authorKuvardina, Olga N.-
dc.contributor.authorMeyer, Annekarin-
dc.contributor.authorOellerich, Thomas-
dc.contributor.authorHäupl, Björn-
dc.contributor.authorSeifried, Erhard-
dc.contributor.authorBonig, Halvard-
dc.contributor.authorLausen, Joern-
dc.date.accessioned2023-05-25T09:56:43Z-
dc.date.available2023-05-25T09:56:43Z-
dc.date.issued2021de
dc.identifier.issn2157-9024-
dc.identifier.other1847385958-
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-130899de
dc.identifier.urihttp://elib.uni-stuttgart.de/handle/11682/13089-
dc.identifier.urihttp://dx.doi.org/10.18419/opus-13070-
dc.description.abstractThe establishment of cell type specific gene expression by transcription factors and their epigenetic cofactors is central for cell fate decisions. Protein arginine methyltransferase 6 (PRMT6) is an epigenetic regulator of gene expression mainly through methylating arginines at histone H3. This way it influences cellular differentiation and proliferation. PRMT6 lacks DNA-binding capability but is recruited by transcription factors to regulate gene expression. However, currently only a limited number of transcription factors have been identified, which facilitate recruitment of PRMT6 to key cell cycle related target genes. Here, we show that LEF1 contributes to the recruitment of PRMT6 to the central cell cycle regulator CCND1 (Cyclin D1). We identified LEF1 as an interaction partner of PRMT6. Knockdown of LEF1 or PRMT6 reduces CCND1 expression. This is in line with our observation that knockdown of PRMT6 increases the number of cells in G1 phase of the cell cycle and decreases proliferation. These results improve the understanding of PRMT6 activity in cell cycle regulation. We expect that these insights will foster the rational development and usage of specific PRMT6 inhibitors for cancer therapy.en
dc.description.sponsorshipWilhelm Sander-Stiftungde
dc.description.sponsorshipDeutsche Forschungsgemeinschaftde
dc.language.isoende
dc.relation.uridoi:10.1038/s41389-021-00332-zde
dc.rightsinfo:eu-repo/semantics/openAccessde
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subject.ddc570de
dc.titlePRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1en
dc.typearticlede
dc.date.updated2023-03-28T03:57:02Z-
ubs.fakultaetEnergie-, Verfahrens- und Biotechnikde
ubs.fakultaetFakultätsübergreifend / Sonstige Einrichtungde
ubs.institutInstitut für Industrielle Genetikde
ubs.institutFakultätsübergreifend / Sonstige Einrichtungde
ubs.publikation.seiten14de
ubs.publikation.sourceOncogenesis 10 (2021), No. 42de
ubs.publikation.typZeitschriftenartikelde
Enthalten in den Sammlungen:04 Fakultät Energie-, Verfahrens- und Biotechnik

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