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Autor(en): Damakoudi, Vassiliki
Feldner, Tobias
Dilji, Edina
Belkin, Andrey
Richert, Clemens
Titel: Hybridization networks of mRNA and branched RNA hybrids
Erscheinungsdatum: 2020
Dokumentart: Zeitschriftenartikel
Seiten: 924-930
Erschienen in: ChemBioChem 22 (2021), S. 924-930
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-144278
http://elib.uni-stuttgart.de/handle/11682/14427
http://dx.doi.org/10.18419/opus-14408
ISSN: 1439-7633
1439-4227
Zusammenfassung: Messenger RNA (mRNA) is emerging as an attractive biopolymer for therapy and vaccination. To become suitable for vaccination, mRNA is usually converted to a biomaterial, using cationic peptides, polymers or lipids. An alternative form of converting mRNA into a material is demonstrated that uses branched oligoribonucleotide hybrids with the ability to hybridize with one or more regions of the mRNA sequence. Two such hybrids with hexamer arms and adamantane tetraol as branching element were prepared by solution‐phase synthesis. When a rabies mRNA was treated with the branched hybrids at 1 M NaCl concentration, biomaterials formed that contained both of the nucleic acids. These results show that branched oligoribonucleotides are an alternative to the often toxic reagents commonly used to formulate mRNA for medical applications.
Enthalten in den Sammlungen:03 Fakultät Chemie

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