6-Hydroxydopamine lesion of the rat prefrontal cortex impairs motor initiation but not motor execution

Hauber, Wolfgang; Bubser, Michael; Schmidt, Werner J.

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DC Element	Wert	Sprache
dc.contributor.author	Hauber, Wolfgang	de
dc.contributor.author	Bubser, Michael	de
dc.contributor.author	Schmidt, Werner J.	de
dc.date.accessioned	2009-04-03	de
dc.date.accessioned	2016-03-31T07:52:22Z	-
dc.date.available	2009-04-03	de
dc.date.available	2016-03-31T07:52:22Z	-
dc.date.issued	1994	de
dc.identifier.other	314176365	de
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39727	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/1814	-
dc.identifier.uri	http://dx.doi.org/10.18419/opus-1797	-
dc.description.abstract	We examined the effects of bilateral 6-hydroxydopamine (6-OHDA) lesions of the medial prefrontal cortex (PFC) in rats on motor initiation and execution in a simple reaction time task. Reaction times (RT) and movement times (MT) were measured in trained rats on four preand postoperative days. Animals with 6-OHDA lesions were selectively impaired on motor initiation as measured by a significant increase in RT on each postoperative day. Motor execution was intact postoperatively, since MT was not altered. Neurochemical analysis revealed a significant depletion of prefrontal dopamine (DA) and noradrenaline (NA) in lesioned animals. It was concluded that DA and, to a lesser extent, NA in the rat PFC were involved in monitoring RT performance.	en
dc.language.iso	en	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.subject.classification	Präfrontaler Cortex , Dopamin , Reaktionszeit , Ratte	de
dc.subject.ddc	570	de
dc.subject.other	Prefrontal cortex , 6-Hydroxydopamine , Dopamine , Noradrenaline , Reaction and movement times , Rat	en
dc.title	6-Hydroxydopamine lesion of the rat prefrontal cortex impairs motor initiation but not motor execution	en
dc.type	article	de
dc.date.updated	2014-10-16	de
ubs.fakultaet	Fakultät Energie-, Verfahrens- und Biotechnik	de
ubs.fakultaet	Fakultätsübergreifend / Sonstige Einrichtung	de
ubs.institut	Institut für Biomaterialien und biomolekulare Systeme	de
ubs.institut	Sonstige Einrichtung	de
ubs.opusid	3972	de
ubs.publikation.source	Experimental brain research 99 (1994), S. 524-528. URL http://dx.doi.org./10.1007/BF00228988	de
ubs.publikation.typ	Zeitschriftenartikel	de
Enthalten in den Sammlungen:	04 Fakultät Energie-, Verfahrens- und Biotechnik

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