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http://dx.doi.org/10.18419/opus-1911
Autor(en): | Witt, Johannes Barisic, Sandra Sawodny, Oliver Ederer, Michael Kulms, Dagmar Sauter, Thomas |
Titel: | Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation |
Erscheinungsdatum: | 2011 |
Dokumentart: | Zeitschriftenartikel |
Erschienen in: | EURASIP journal on bioinformatics and systems biology (2011), 2011:3. URL http://dx.doi.org./10.1186/1687-4153-2011-3 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-64896 http://elib.uni-stuttgart.de/handle/11682/1928 http://dx.doi.org/10.18419/opus-1911 |
Zusammenfassung: | Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NFκB activation caused by continuous IKKbeta phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKKbeta phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets. |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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witt11_additionalFile.pdf | Additional file | 37,76 kB | Adobe PDF | Öffnen/Anzeigen |
witt11.pdf | Full text | 350,36 kB | Adobe PDF | Öffnen/Anzeigen |
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