Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen: http://dx.doi.org/10.18419/opus-1911
Autor(en): Witt, Johannes
Barisic, Sandra
Sawodny, Oliver
Ederer, Michael
Kulms, Dagmar
Sauter, Thomas
Titel: Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation
Erscheinungsdatum: 2011
Dokumentart: Zeitschriftenartikel
Erschienen in: EURASIP journal on bioinformatics and systems biology (2011), 2011:3. URL http://dx.doi.org./10.1186/1687-4153-2011-3
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-64896
http://elib.uni-stuttgart.de/handle/11682/1928
http://dx.doi.org/10.18419/opus-1911
Zusammenfassung: Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NFκB activation caused by continuous IKKbeta phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKKbeta phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets.
Enthalten in den Sammlungen:04 Fakultät Energie-, Verfahrens- und Biotechnik

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
witt11_additionalFile.pdfAdditional file37,76 kBAdobe PDFÖffnen/Anzeigen
witt11.pdfFull text350,36 kBAdobe PDFÖffnen/Anzeigen


Alle Ressourcen in diesem Repositorium sind urheberrechtlich geschützt.