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http://dx.doi.org/10.18419/opus-1961
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Paschke, Dietmar | de |
dc.contributor.author | Eckert, Reiner | de |
dc.contributor.author | Hülser, Dieter F. | de |
dc.date.accessioned | 2011-12-05 | de |
dc.date.accessioned | 2016-03-31T07:53:05Z | - |
dc.date.available | 2011-12-05 | de |
dc.date.available | 2016-03-31T07:53:05Z | - |
dc.date.issued | 1992 | de |
dc.identifier.other | 360089836 | de |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-69099 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/1978 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-1961 | - |
dc.description.abstract | Antibodies against the main proteins in hepatic gap junctions - connexin-26 and connexin-32 - have been used in conjunction with high-resolution patch-clamp techniques to investigate whether a relation exists between connexin type and conductance of single gap-junctional channels. Two different cell lines, BRL cells, derived from rat liver, and FL cells a human amniotic cell line exhibited the same single-channel conductances in double whole-cell recordings, but reacted differently upon dialysis with antibodies. Preliminary results indicate that both cell lines express mainly connexin-43. Thus, in spite of the inhibitory action of anti-cx26 and anti-cx32 antibodies observed, the data question the reliability of these antibodies for the functional characterization of gap-junction proteins in electrophysiological experiments. | en |
dc.language.iso | en | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.subject.classification | Gap junction , Zellkultur , Patch-Clamp-Methode | de |
dc.subject.ddc | 570 | de |
dc.title | High-resolution measurements of gap-junctional conductance during perfusion with anti-connexin antibodies in pairs of cultured mammalian cells | en |
dc.type | article | de |
ubs.fakultaet | Fakultät Energie-, Verfahrens- und Biotechnik | de |
ubs.institut | Institut für Biomaterialien und biomolekulare Systeme | de |
ubs.opusid | 6909 | de |
ubs.publikation.source | Pflügers Archiv 420 (1992), S. 87-93. URL http://dx.doi.org./10.1007/BF00378646 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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huel78.pdf | 927,98 kB | Adobe PDF | Öffnen/Anzeigen |
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