Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-2008
Rubio, Miguel Angel
|Title:||Bacterial metabolism of side-chain-fluorinated aromatics: unproductive meta-cleavage of 3-trifluoromethylcatechol|
|metadata.ubs.publikation.source:||Applied microbiology and biotechnology 32 (1990), S. 600-608. URL http://dx.doi.org./10.1007/BF00173734|
|Abstract:||Sixteen bacterial strains capable of degrading alkylbenzenes and alkylphenols were directly isolated from soil and water. The degradation pathways are discussed. Alkylcatechols are almost exclusively cleaved via meta-ring fission. Meta-cleavage of 3-trifluoromethyl-(TFM)-catechol was observed with all strains at different rates although the reaction rates compared to catechol as a substrate varied considerably. All 2-hydroxy-6-oxohepta-2,4-dienoic acid hydrolases investigated showed strong binding of 7,7,7-trifluoro-2-hydroxy-6-oxohepta-2,4-dienoic acid, the ring fission product of 3-TFM-catechol. Turnover rates, however, were negligible indicating this compound to be a general dead-end metabolite during metabolism of TFM-substituted compounds via meta-cleavage pathways.|
|Appears in Collections:||04 Fakultät Energie-, Verfahrens- und Biotechnik|
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