Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-7779
|Authors:||Rajewsky, Manfred F.|
Augenlicht, Leonard H.
Hülser, Dieter F.
Laerum, Ole D.
Lomakina, L. Ya.
|Title:||Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects|
|metadata.ubs.publikation.source:||Hiatt, H. H. (Hrsg.): Origins of human cancer. B. Cold Spring Harbor : Cold Spring Harbor Laboratory, 1977 (Cold Spring Harbor conferences on cell proliferation 4), S. 709-726|
|Abstract:||A lead in the search for cellular determinants favoring neoplastic transformation may be provided by the pronounced tissue specificity of the oncogenic effect of certain carcinogens which do not require enzymatic metabolic activation, i.e., in cases where this specificity cannot be due to tissue differences in the activity of enzymes involved in the formation of the ultimate reactants. A carcinogen that fulfills this condition is the ethylating agent N-ethyl-N-nitrosourea (EtNU). Alkylation of nucleic acid constituents by N-nitroso compounds in relation to mutagenesis and carcinogenesis has received considerable attention recently.|
|Appears in Collections:||15 Fakultätsübergreifend / Sonstige Einrichtung|
Items in OPUS are protected by copyright, with all rights reserved, unless otherwise indicated.