Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-7779
Authors: Rajewsky, Manfred F.
Augenlicht, Leonard H.
Biessmann, Harald
Goth, Regine
Hülser, Dieter F.
Laerum, Ole D.
Lomakina, L. Ya.
Title: Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects
Issue Date: 1977
metadata.ubs.publikation.typ: Konferenzbeitrag
metadata.ubs.publikation.source: Hiatt, H. H. (Hrsg.): Origins of human cancer. B. Cold Spring Harbor : Cold Spring Harbor Laboratory, 1977 (Cold Spring Harbor conferences on cell proliferation 4), S. 709-726
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68126
http://elib.uni-stuttgart.de/handle/11682/7796
http://dx.doi.org/10.18419/opus-7779
Abstract: A lead in the search for cellular determinants favoring neoplastic transformation may be provided by the pronounced tissue specificity of the oncogenic effect of certain carcinogens which do not require enzymatic metabolic activation, i.e., in cases where this specificity cannot be due to tissue differences in the activity of enzymes involved in the formation of the ultimate reactants. A carcinogen that fulfills this condition is the ethylating agent N-ethyl-N-nitrosourea (EtNU). Alkylation of nucleic acid constituents by N-nitroso compounds in relation to mutagenesis and carcinogenesis has received considerable attention recently.
Appears in Collections:15 Fakultätsübergreifend / Sonstige Einrichtung

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