Membrane trafficking in breast cancer progression : protein kinase D comes into play

Gutiérrez-Galindo, Elena; Yilmaz, Zeynep Hazal; Hausser, Angelika

Membrane trafficking in breast cancer progression : protein kinase D comes into play

dc.contributor.author	Gutiérrez-Galindo, Elena
dc.contributor.author	Yilmaz, Zeynep Hazal
dc.contributor.author	Hausser, Angelika
dc.date.accessioned	2023-06-16T12:54:44Z
dc.date.available	2023-06-16T12:54:44Z
dc.date.issued	2023	de
dc.date.updated	2023-06-07T06:30:19Z
dc.description.abstract	Protein kinase D (PKD) is a serine/threonine kinase family that controls important cellular functions, most notably playing a key role in the secretory pathway at the trans-Golgi network. Aberrant expression of PKD isoforms has been found mainly in breast cancer, where it promotes various cellular processes such as growth, invasion, survival and stem cell maintenance. In this review, we discuss the isoform-specific functions of PKD in breast cancer progression, with a particular focus on how the PKD controlled cellular processes might be linked to deregulated membrane trafficking and secretion. We further highlight the challenges of a therapeutic approach targeting PKD to prevent breast cancer progression.	en
dc.identifier.issn	2296-634X
dc.identifier.other	185126261X
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-131900	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/13190
dc.identifier.uri	http://dx.doi.org/10.18419/opus-13171
dc.language.iso	en	de
dc.relation	info:eu-repo/grantAgreement/EC/H2020/859962	de
dc.relation.uri	doi:10.3389/fcell.2023.1173387	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	de
dc.subject.ddc	570	de
dc.subject.ddc	610	de
dc.title	Membrane trafficking in breast cancer progression : protein kinase D comes into play	en
dc.type	article	de
ubs.fakultaet	Energie-, Verfahrens- und Biotechnik	de
ubs.fakultaet	Fakultäts- und hochschulübergreifende Einrichtungen	de
ubs.institut	Institut für Zellbiologie und Immunologie	de
ubs.institut	Stuttgart Research Center Systems Biology (SRCSB)	de
ubs.publikation.seiten	14	de
ubs.publikation.source	Frontiers in cell and developmental biology 11 (2023), No. 1173387	de
ubs.publikation.typ	Zeitschriftenartikel	de

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