Enzyme-catalyzed synthesis of (S)-cyanohydrins and subsequent hydrolysis to (S)-α-hydroxy-carboxylic acids

Effenberger, FranzHörsch, BrigitteFörster, SiegfriedZiegler, Thomas2009-08-272016-03-312009-08-272016-03-311990312054513http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-43691http://elib.uni-stuttgart.de/handle/11682/1139http://dx.doi.org/10.18419/opus-1122(S)-Cyanohydrins 2 are obtained with high enantioselectivity from aromatic aldehydes and HCN in the presence of (S)-oxynitrilase (E.C.4.1.2.11). Acid-catalyzed hydrolysis of the cyanohydrins 2 affords the corresponding (S)-α-hydroxy carboxylic acids 3 without racemization.eninfo:eu-repo/semantics/openAccessEnzymkatalyse , Cyanohydrine , Carbonsäuren540Enzyme-catalyzed synthesis of (S)-cyanohydrins and subsequent hydrolysis to (S)-α-hydroxy-carboxylic acidsarticle2009-10-20