Hauber, WolfgangBubser, MichaelSchmidt, Werner J.2009-04-032016-03-312009-04-032016-03-311994314176365http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39727http://elib.uni-stuttgart.de/handle/11682/1814http://dx.doi.org/10.18419/opus-1797We examined the effects of bilateral 6-hydroxydopamine (6-OHDA) lesions of the medial prefrontal cortex (PFC) in rats on motor initiation and execution in a simple reaction time task. Reaction times (RT) and movement times (MT) were measured in trained rats on four preand postoperative days. Animals with 6-OHDA lesions were selectively impaired on motor initiation as measured by a significant increase in RT on each postoperative day. Motor execution was intact postoperatively, since MT was not altered. Neurochemical analysis revealed a significant depletion of prefrontal dopamine (DA) and noradrenaline (NA) in lesioned animals. It was concluded that DA and, to a lesser extent, NA in the rat PFC were involved in monitoring RT performance.eninfo:eu-repo/semantics/openAccessPräfrontaler Cortex , Dopamin , Reaktionszeit , Ratte570Prefrontal cortex , 6-Hydroxydopamine , Dopamine , Noradrenaline , Reaction and movement times , Ratarticle2014-10-16