Effenberger, FranzHopf, MartinZiegler, ThomasHudelmayer, Jochen2009-08-272016-03-312009-08-272016-03-311991316177512http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-43953http://elib.uni-stuttgart.de/handle/11682/1160http://dx.doi.org/10.18419/opus-1143The synthesis of O-silyl- and O-benzyl-protected (R)-2-hydroxy aldehydes (R)-6 from (R)-2-hydroxy carboxylic acids (R)-1 is described. While attempts for their diastereoselective hydrocyanation with hydrocyanic acid and (R)-oxynitrilase as catalyst have not been successful, the cyano silylation with trimethylsilyl cyanide occurred diastereoselectively with a ratio of 81 : 19 preferring the threo form without racemization at C-2 of the 2-hydroxy aldehyde.deinfo:eu-repo/semantics/openAccessHydrocyanierung , Enzymkatalyse , Hydroxyaldehyde540article2010-09-30