Effenberger, FranzStraub, AlexanderNull, Volker2009-08-282016-03-312009-08-282016-03-311992316220310http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-44387http://elib.uni-stuttgart.de/handle/11682/1176http://dx.doi.org/10.18419/opus-1159A novel synthesis for thiosugars starting from achiral compounds by using enzymes as catalysts is described. 5-Thio-D-threo-2-pentulofuranose (4), for example, is prepared either by the RAMA (rabbit muscle aldolase)-catalyzed reaction of mercaptoacetaldehyde (1b) with dihydroxyacetonephosphate (2) or by the yeast transketolase-catalyzed reaction of 2-hydroxy-3-mercaptopanal (R/S)-6 with lithium 3-hydroxypyruvate (9). 6-Thio-D-arabino-2-hexulopyranose (8a) and 6-thio-L-xylo-2-hexulopyranose (8b) are obtained by the RAMA-catalyzed reaction of racemic (R/S)-6 with 2.deinfo:eu-repo/semantics/openAccessThiophenderivate , Transketolase , Enzymkatalyse540article