Navas-Carretero, SantiagoSan-Cristobal, RodrigoSiig Vestentoft, PiaBrand-Miller, Jennie C.Jalo, ElliWesterterp-Plantenga, MargrietSimpson, Elizabeth J.Handjieva-Darlenska, TeodoraStratton, GarethHuttunen-Lenz, MaijaLam, TonyMuirhead, RoslynPoppitt, SallyPietiläinen, Kirsi H.Adam, TanjaTaylor, Moira A.Handjiev, SvetoslavMcNarry, Melitta A.Hansen, SylviaBrodie, ShannonSilvestre, Marta P.Macdonald, Ian A.Boyadjieva, NadkaMackintosh, Kelly A.Schlicht, WolfgangLiu, AmyLarsen, Thomas M.Fogelholm, MikaelRaben, AnneMartinez, J. Alfredo2023-09-132023-09-1320212296-861X1866252429http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-135180http://elib.uni-stuttgart.de/handle/11682/13518http://dx.doi.org/10.18419/opus-13499Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D.eninfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/570610article2021-11-15