Hauber, WolfgangAndersen, Ragna2009-04-032016-03-312009-04-032016-03-31199331417687Xhttp://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39746http://elib.uni-stuttgart.de/handle/11682/1815http://dx.doi.org/10.18419/opus-1798The effects of the non-NMDA glutamate receptor antagonist GYKI 52466 (2.4 and 4.8 mg/kg, i.p.) on spontaneous locomotor activity and haloperidol-induced catalepsy (0.5 mg/kg, i.p.) were assessed in naive rats and in rats pretreated with the NMDA antagonist dizocilpine (0.08 mg/kg, i.p.). GYKI 52466 given alone did not alter locomotor activity and haloperidol-induced catalepsy, but significantly antagonized the dizocilpine-induced locomotor stimulation and counteracted the anti-cataleptic effects of dizocilpine on haloperidol-induced catalepsy. Thus blockade of non-NMDA glutamate receptors antagonized the behavioural stimulant effects of a NMDA receptor blockade.eninfo:eu-repo/semantics/openAccessNMDA-Rezeptor , Ratte , Katalepsie570NMDA receptors , Non-NMDA receptors , Dizocilpine , GYKI 52466 , Locomotion , Haloperido , induced catalepsy , Ratarticle2013-05-27