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http://dx.doi.org/10.18419/opus-6916
Autor(en): | Hauber, Wolfgang Schmidt, Werner J. |
Titel: | The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits |
Erscheinungsdatum: | 1990 |
Dokumentart: | Zeitschriftenartikel |
Erschienen in: | Behavioural Brain Research 41 (1990), S. 161-166. URL http://dx.doi.org./10.1016/0166-4328(90)90151-4 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39703 http://elib.uni-stuttgart.de/handle/11682/6933 http://dx.doi.org/10.18419/opus-6916 |
Zusammenfassung: | The present study shows that systemic dopamine receptor blockade impaired movement initiation of rats, trained in a simple reaction time task for rapid initiation of locomotion in response to a combined optic/acoustic cue. Reaction time, movement time and the accelerative force were recorded for each initiation of locomotion. Results indicate a dose-related increase of reaction time following systemic administration of haloperidol (0.1, 0.15, 0.3 mg/kg i.p.). Measures derived from resulting force-time patterns showed a haloperidol-induced decrease (0.15 mg/kg i.p.) of the mean rate of force development, indicating a decreased initial acceleration. These effects were reversed by systemic co-administration of dizocilpine (MK-801) (0.08 mg/kg i.p.), a selective non-competitive N-methyl-d-aspartate (NMDA) antagonist. The haloperidol-induced movement initiation deficits in this task are in part comparable to akinesia seen in Parkinson's disease and their reversal by dizocilpine has implications for the treatment of this disease. |
Enthalten in den Sammlungen: | 15 Fakultätsübergreifend / Sonstige Einrichtung |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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hau8.pdf | 492,79 kB | Adobe PDF | Öffnen/Anzeigen |
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