Browsing by Author "Eilingsfeld, Adrian"

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    Investigation of the impact of different scale-up dependent stimuli on metabolism and population heterogeneity in Corynebacterium glutamicum
    (2024) Eilingsfeld, Adrian; Takors, Ralf (Prof. Dr.-Ing.)
    This thesis investigates the impact of elevated carbon dioxide levels on population heterogeneity in Corynebacterium glutamicum, a widely used industrial production host. Through a series of experiments involving cultivation at varying CO2 partial pressures, flow cytometry, and analysis of DNA content, the research reveals that increased CO2 exerts significant selection pressure, affecting growth rates and cell aggregation tendencies. Key findings indicate that higher growth rates speed up DNA replication levels, while elevated CO2 levels slow them down. The results contribute to understanding how CO2 influences population dynamics, providing insights for optimizing industrial bioprocesses and support Corynebacterium glutamicum as a robust production strain.