Browsing by Author "Jacques, Cécile"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    ItemOpen Access
    Self-generated gradients steer collective migration on viscoelastic collagen networks
    (2022) Clark, Andrew G.; Maitra, Ananyo; Jacques, Cécile; Bergert, Martin; Pérez-González, Carlos; Simon, Anthony; Lederer, Luc; Diz-Muñoz, Alba; Trepat, Xavier; Voituriez, Raphaël; Matic Vignjevic, Danijela
    Growing evidence suggests that the physical properties of the cellular microenvironment influence cell migration. However, it is not currently understood how active physical remodelling by cells affects migration dynamics. Here we report that cell clusters seeded on deformable collagen-I networks display persistent collective migration despite not showing any apparent intrinsic polarity. Clusters generate transient gradients in collagen density and alignment due to viscoelastic relaxation of the collagen networks. Combining theory and experiments, we show that crosslinking collagen networks or reducing cell cluster size results in reduced network deformation, shorter viscoelastic relaxation time and smaller gradients, leading to lower migration persistence. Traction force and Brillouin microscopy reveal asymmetries in force distributions and collagen stiffness during migration, providing evidence of mechanical cross-talk between cells and their substrate during migration. This physical model provides a mechanism for self-generated directional migration on viscoelastic substrates in the absence of internal biochemical polarity cues.