Ipso substitution of heterocyclic trimethylsilyl carboxylates by carbon electrophiles

Abstract

Trimethysilyl esters 1 of heterocyclic carboxylic acids having the ester group in the α-position to an azine nitrogen atom react with aldehydes or ketones through ipso substitution of the ester group to give (trimethylsiloxy)-alkyl-substituted heterocyclic products in good yields.