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Autor(en): Dufner, Lukas
Oßwald, Bettina
Eberspaecher, Jan
Riedel, Bianca
Kling, Chiara
Kern, Frank
Seidenstuecker, Michael
Titel: Adjustment of micro- and macroporosity of ß-TCP scaffolds using solid-stabilized foams as bone replacement
Erscheinungsdatum: 2023
Dokumentart: Zeitschriftenartikel
Seiten: 19
Erschienen in: Bioengineering 10 (2023), No. 256
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-127967
http://elib.uni-stuttgart.de/handle/11682/12796
http://dx.doi.org/10.18419/opus-12777
ISSN: 2306-5354
Zusammenfassung: To enable rapid osteointegration in bioceramic implants and to give them osteoinductive properties, scaffolds with defined micro- and macroporosity are required. Pores or pore networks promote the integration of cells into the implant, facilitating the supply of nutrients and the removal of metabolic products. In this paper, scaffolds are created from ß-tricalciumphosphate (ß-TCP) and in a novel way, where both the micro- and macroporosity are adjusted simultaneously by the addition of pore-forming polymer particles. The particles used are 10-40 wt%, spherical polymer particles of polymethylmethacrylate (PMMA) (Ø = 5 m) and alternatively polymethylsilsesquioxane (PMSQ) (Ø = 2 m), added in the course of ß-TCP slurry preparation. The arrangement of hydrophobic polymer particles at the interface of air bubbles was incorporated during slurry preparation and foaming of the slurry. The foam structures remain after sintering and lead to the formation of macro-porosity in the scaffolds. Furthermore, decomposition of the polymer particles during thermal debindering results in the formation of an additional network of interconnecting micropores in the stabilizing structures. It is possible to adjust the porosity easily and quickly in a range of 1.2-140 m with a relatively low organic fraction. The structures thus prepared showed no cytotoxicity nor negative effects on the biocompatibility.
Enthalten in den Sammlungen:07 Fakultät Konstruktions-, Produktions- und Fahrzeugtechnik

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