Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-1795
Authors: Hauber, Wolfgang
Schmidt, Werner J.
Title: Discrete quinolinic acid lesions of the lateral but not of the medial caudate putamen reversed haloperidol-induced catalepsy in rats
Issue Date: 1993
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Journal of neural transmission 94 (1994), S. 103-114. URL http://dx.doi.org./10.1007/BF01245004
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39680
http://elib.uni-stuttgart.de/handle/11682/1812
http://dx.doi.org/10.18419/opus-1795
Abstract: Discrete lesions in the medial or lateral subregion of the rostral caudate-putamen (CP) were induced by bilateral intracerebral injections of a low dose of quinolinic acid (30 nmol in 1 mgrl/per side) in rats. Quinolinic acid lesions in the lateral CP potently reversed haloperidol-induced catalepsy (0.5 mg/ kg,i.p.), while lesions in the medial CP were not effective. Spontaneous locomotor activity was not altered significantly after quinolinic acid lesions of either the medial or lateral CP. These results show that the lateral CP seems to be important for the expression of neuroleptic-induced catalepsy and thus further corroborate the concept of a functional heterogenity of the striatum
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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