Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-1796
Authors: Hauber, Wolfgang
Schmidt, Werner J.
Title: Effects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasks
Issue Date: 1989
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Journal of neural transmission 78 (1989), S. 29-41. URL http://dx.doi.org./10.1007/BF01247111
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39716
http://elib.uni-stuttgart.de/handle/11682/1813
http://dx.doi.org/10.18419/opus-1796
Abstract: Prefrontal cortex and neostriatum constituting the prefrontal system are connected by glutamatergic neurones. The involvement of this corticostriatal projection in control of maze performance of rats was investigated. Glutamatergic transmission mediated by N-methyl-D-aspartate (NMDA) receptors was blocked by intrastriatal injections of dl-2-amino-5-phosphonovaleric acid (AP-5) (50 nmole in 0.5 Mgrl). In experiment 1, intrastriatal AP-5 was found to increase the number of errors during acquisition of a delayed alternation task in a T-maze. In experiment 2, the effect of intrastriatal AP-5 on acquisition of different 8 arm maze tasks was investigated. AP-5 did not affect the number of reentries on spontaneous and reinforced alternation; pre- and postdelay errors on delayed alternation were not altered. Therefore, intrastriatal NMDA receptor blockade impairs acquisition of a delayed alternation in a T-maze, while intrastriatal blockade of NMDA receptors does not affect acquisition of different 8 arm maze tasks.
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

Files in This Item:
File Description SizeFormat 
hau11.pdf969,47 kBAdobe PDFView/Open


Items in OPUS are protected by copyright, with all rights reserved, unless otherwise indicated.