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dc.contributor.authorHauber, Wolfgangde
dc.contributor.authorSchmidt, Werner J.de
dc.date.accessioned2009-04-03de
dc.date.accessioned2016-03-31T07:52:22Z-
dc.date.available2009-04-03de
dc.date.available2016-03-31T07:52:22Z-
dc.date.issued1989de
dc.identifier.other314175520de
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39716de
dc.identifier.urihttp://elib.uni-stuttgart.de/handle/11682/1813-
dc.identifier.urihttp://dx.doi.org/10.18419/opus-1796-
dc.description.abstractPrefrontal cortex and neostriatum constituting the prefrontal system are connected by glutamatergic neurones. The involvement of this corticostriatal projection in control of maze performance of rats was investigated. Glutamatergic transmission mediated by N-methyl-D-aspartate (NMDA) receptors was blocked by intrastriatal injections of dl-2-amino-5-phosphonovaleric acid (AP-5) (50 nmole in 0.5 Mgrl). In experiment 1, intrastriatal AP-5 was found to increase the number of errors during acquisition of a delayed alternation task in a T-maze. In experiment 2, the effect of intrastriatal AP-5 on acquisition of different 8 arm maze tasks was investigated. AP-5 did not affect the number of reentries on spontaneous and reinforced alternation; pre- and postdelay errors on delayed alternation were not altered. Therefore, intrastriatal NMDA receptor blockade impairs acquisition of a delayed alternation in a T-maze, while intrastriatal blockade of NMDA receptors does not affect acquisition of different 8 arm maze tasks.en
dc.language.isoende
dc.rightsinfo:eu-repo/semantics/openAccessde
dc.subject.classificationNMDA-Rezeptor , Gedächtnis , Glutamate , Rattede
dc.subject.ddc570de
dc.subject.otherLearning and memory , interference , striatum , glutamate , NMDA receptor , AP-5 , raten
dc.titleEffects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasksen
dc.typearticlede
dc.date.updated2014-10-16de
ubs.fakultaetFakultät Energie-, Verfahrens- und Biotechnikde
ubs.fakultaetFakultätsübergreifend / Sonstige Einrichtungde
ubs.institutInstitut für Biomaterialien und biomolekulare Systemede
ubs.institutSonstige Einrichtungde
ubs.opusid3971de
ubs.publikation.sourceJournal of neural transmission 78 (1989), S. 29-41. URL http://dx.doi.org./10.1007/BF01247111de
ubs.publikation.typZeitschriftenartikelde
Enthalten in den Sammlungen:04 Fakultät Energie-, Verfahrens- und Biotechnik

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