Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.18419/opus-1954
Autor(en): | Bräuner, Thomas Hülser, Dieter F. |
Titel: | Tumor cell invasion and gap junctional communication. 2, Normal and malignant cells confronted in multicell spheroids |
Erscheinungsdatum: | 1990 |
Dokumentart: | Zeitschriftenartikel |
Erschienen in: | Invasion metastasis 10 (1990), S. 31-48 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68828 http://elib.uni-stuttgart.de/handle/11682/1971 http://dx.doi.org/10.18419/opus-1954 |
Zusammenfassung: | The invasive behavior of five tumor cell lines was investigated with an in vitro invasion assay developed by Mareel et al. Spheroids of all 5 cell lines readily attached to precultured heart fragments (PHF), resulting in confronting pairs. Tumor cells (8ICR/MIR k C6, and EMT6/Ro) which communicated with the host tissue via gap junctions, rapidly invaded the PHF within 3 days. Population doubling time or migratory activities had no influence on the invasion process. The noncoupled HeLa and L cells formed a cellular capsule around the PHF and showed no invasive activities. HeLa cells, however, started to destroy the PHF after 4 days. We suggest a mechanism different from that of coupled tumor cells. Epithelioid HeLa cells are linked by numerous tight junctions and may, therefore, cut off the nutrition supply for the inner-laying PHF, resulting in a disintegration of the heart tissue. |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
huel63.pdf | 3,26 MB | Adobe PDF | Öffnen/Anzeigen |
Alle Ressourcen in diesem Repositorium sind urheberrechtlich geschützt.