Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-5688
Authors: Heidlauf, Thomas
Röhrle, Oliver
Title: Modeling the chemoelectromechanical behavior of skeletal muscle using the parallel open-source software library OpenCMISS
Issue Date: 2013
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Computational and mathematical methods in medicine (2013), article ID 517287. URL http://dx.doi.org/10.1155/2013/517287
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-86696
http://elib.uni-stuttgart.de/handle/11682/5705
http://dx.doi.org/10.18419/opus-5688
Abstract: An extensible, flexible, multiscale and multiphysics model for non-isometric skeletal muscle behavior is presented. The skeletal muscle chemoelectromechanical model is based on a bottom-up approach modeling the entire excitation-contraction pathway by strongly coupling a detailed biophysical model of a half-sarcomere to the propagation of action potentials along skeletal muscle fibers, and linking cellular parameters to a transversely isotropic continuum-mechanical constitutive equation describing the overall mechanical behavior of skeletal muscle tissue. Since the multiscale model exhibits separable time scales, a special emphasis is placed on employing computationally efficient staggered solution schemes. Further, the implementation builds on the open-source software library OpenCMISS and uses state-ofthe-art parallelization techniques taking advantage of the unique anatomical fiber architecture of skeletal muscles. OpenCMISS utilizes standardized data structures for geometrical aspects (FieldML) and cellular models (CellML). Both standards are designed to allow for a maximum on flexibility, reproducibility, and extensibility. The results demonstrate the model´s capability of simulating different aspects of non-isometric muscle contraction and to efficiently simulate the chemoelectromechanical behavior in complex skeletal muscles such as the tibialis anterior muscle.
Appears in Collections:11 Interfakultäre Einrichtungen

Files in This Item:
File Description SizeFormat 
final_printed.pdf2,74 MBAdobe PDFView/Open


Items in OPUS are protected by copyright, with all rights reserved, unless otherwise indicated.