Untersuchung der Karzinogenität der Photooxidationsprodukte von Benzo(a)pyren

Abstract

The photodegradation products of benzo(a)pyrene (BP) were studied for their possible carcinogenicity. Oxidation of the BP-solutions was accomplished with SWD-120 lamp irradiation. 0,5 ml of the oil solution of the BP-degradation products (aquivalent to 2 mg BP) were injected into mice F1 (C57B1 x CBA). After a year period the mice were killed and a total number of tumors at the site of inoculation (different types of sacroma) was studied. The number of tumors correlated with the quantity of intact BP-products of BP-degradation seems to have no carcinogenic activity, thus BP-photodegradation is supposed to be a method for its decarcinogenization.