Diastereoselective synthesis of amino-substituted indolizidines and quinolizidines by the intramolecular hetero-ene reaction of prolinal imine and 2-piperidine carbaldimine

Abstract

We have concerned ourselves with the question of the extent to which diastereoselectively substituted indolizidines and quinolizidines can be constructed with such hetero-ene reactions particularly in view of the fact that a range of these alkaloid derivatives are effective glucosidase inhibitors and are thus of increasing interest because of their Anti-HIV activity.