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dc.contributor.authorDertinger, Hermannde
dc.contributor.authorHülser, Dieter F.de
dc.date.accessioned2011-11-16de
dc.date.accessioned2016-03-31T11:44:16Z-
dc.date.available2011-11-16de
dc.date.available2016-03-31T11:44:16Z-
dc.date.issued1984de
dc.identifier.other368324087de
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68626de
dc.identifier.urihttp://elib.uni-stuttgart.de/handle/11682/7804-
dc.identifier.urihttp://dx.doi.org/10.18419/opus-7787-
dc.description.abstractThis chapter has shown that the response of spheroid cells to gap junctional communication may lead to certain metabolic and cell physiological changes. It has also become apparent that the functions of the gap junctions are very complex. They may, for example, be related to the fundamental effects of cAMP and/or Ca 2+. These lines of evidence should be pursued further. However, further insight into these functions may also be gained from a study of the structure and function of the gap-junctional proteins, as well as from a genetic approach (e.g., Willecke et al. 1982, 1983). In this context, the spheroids are of particular importance as test systems, since they perfectly simulate the three dimensional arrangement of cells encountered in a tissue. Indeed, the results presented in the sections "Biophysical and Biochemical Effects Associated with Intercellular Communications" and "Intercellular Communication and Radiosensitivity" have revealed clear cut differences between cells growing as spheroids or as monolayers in response to communication dependent processes, which indicate that the response of the monolayers could be somewhat trivial. The advantage of multicellular spheroid systems with three-dimensional growth over monolayer cultures is unquestionable. Cells growing in three-dimensional multicell spheroids may re-establish their regulatory activities and, therefore, match the in vivo conditions more closely. Multicell spheroids allow in vitro investigations on differentiating systems and on interactions between normal and malignant cells, thus substituting costly in vivo experiments.en
dc.language.isoende
dc.rightsinfo:eu-repo/semantics/openAccessde
dc.subject.classificationZellkommunikation , Gap junction , Zellkulturde
dc.subject.ddc570de
dc.titleIntercellular communication in spheroidsen
dc.typebookPartde
ubs.fakultaetFakultätsübergreifend / Sonstige Einrichtungde
ubs.institutSonstige Einrichtungde
ubs.opusid6862de
ubs.publikation.sourceAcker, Helmut (Hrsg.): Spheroids in cancer research. Berlin : Springer, 1984 (Recent results in cancer research 95). - ISBN 3-540-13691-6, S. 67-83de
ubs.publikation.typBuchbeitragde
Enthalten in den Sammlungen:15 Fakultätsübergreifend / Sonstige Einrichtung

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