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http://dx.doi.org/10.18419/opus-7795
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Traub, Otto | de |
dc.contributor.author | Eckert, Reiner | de |
dc.contributor.author | Lichtenberg-Fraté, Hella | de |
dc.contributor.author | Elfgang, Claudia | de |
dc.contributor.author | Bastide, Bruno | de |
dc.contributor.author | Scheidtmann, Karl Heinz | de |
dc.contributor.author | Hülser, Dieter F. | de |
dc.contributor.author | Willecke, Klaus | de |
dc.date.accessioned | 2011-12-05 | de |
dc.date.accessioned | 2016-03-31T11:44:17Z | - |
dc.date.available | 2011-12-05 | de |
dc.date.available | 2016-03-31T11:44:17Z | - |
dc.date.issued | 1994 | de |
dc.identifier.other | 363863079 | de |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-69188 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/7812 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-7795 | - |
dc.description.abstract | Human HeLa or SkHep1 cells, defective in intercellular communication through gap junctions, were transfected with coding sequences of murine connexin40 (Cx40) and -43. The transfected cells were restored in gap junctional coupling as shown by 100-fold increased electrical conductance. When studied by the double whole-cell patch-clamp technique, Cx40 HeLa transfectans exhibited single channel conductances of γ=121 ± 7 pS and γ=153 ± 5 pS. They were voltage gated with an equivalent gating charge of z=4.0 ± 0.5 for a voltage of half-maximal inactivation U 9= 44 ± 7 mV. The corresponding values or connexin43 (Cx43) HeLa transfectants are: γ=60 ± 4 pS and γ=40 ± 2 pS as well as z=3.7 ± 0.8 and U 0 = 73 ± 7 mV. Transfer of the dye Lucifer Yellow was always considerably lower in Cx4- than in Cx43-transfectants though their total junctional conductance was similar or even higher than for Cx43-transfectants. | en |
dc.language.iso | en | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.subject.classification | Gap junction , Zellkommunikation , Connexin , HeLa-Zelle | de |
dc.subject.ddc | 570 | de |
dc.title | Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells | en |
dc.type | article | de |
ubs.fakultaet | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.fakultaet | Fakultät Energie-, Verfahrens- und Biotechnik | de |
ubs.institut | Sonstige Einrichtung | de |
ubs.institut | Institut für Biomaterialien und biomolekulare Systeme | de |
ubs.opusid | 6918 | de |
ubs.publikation.source | European journal of cell biology 64 (1994), S. 101-112 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 15 Fakultätsübergreifend / Sonstige Einrichtung |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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huel88.pdf | 2,99 MB | Adobe PDF | Öffnen/Anzeigen |
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