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http://dx.doi.org/10.18419/opus-8224
Autor(en): | Wollnik, Franziska Turek, Fred W. |
Titel: | SCN lesions abolish ultradian and circadian components of activity rhythms in LEW/Ztm rats |
Erscheinungsdatum: | 1989 |
Dokumentart: | Zeitschriftenartikel |
Erschienen in: | American journal of physiology, Regulatory, integrative and comparative physiology 256 (1989), S. R1027-R1039. URL http://ajpregu.physiology.org/content/256/5/R1027 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-92985 http://elib.uni-stuttgart.de/handle/11682/8241 http://dx.doi.org/10.18419/opus-8224 |
Zusammenfassung: | A trimodal locomotor activity pattern has been observed in LEW/Ztm rats. Complete and partial lesions of the suprachiasmatic nucleus (SCN) were used to determine whether the same neural substrate may underlie the circadian rhythms and the ultradian modulation of wheel-running activity in these rats. Whereas sham lesions had little or no effect on the wheel-running activity pattern, complete SCN lesions resulted in a complete loss of circadian and ultradian activity components under free-running or 12:12 h light-dark cycle (12:12 LD) conditions. Ultradian and circadian activity components were still present after partial SCN lesions. Periodogram analysis for any given animal revealed that the ultradian periods were always submultiples of the entrained or free-running circadian period. Furthermore there was a high correlation between the amplitudes of circadian and ultradian spectral estimates, but with a different slope in males and females. These results indicate that in LEW/Ztm rats the SCN contributes to the control of both the circadian wheel-running rhythm and the trimodal ultradian modulation of that behavior. |
Enthalten in den Sammlungen: | 15 Fakultätsübergreifend / Sonstige Einrichtung |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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wol18.pdf | 3,83 MB | Adobe PDF | Öffnen/Anzeigen |
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