Sensoren zur lokusspezifischen Visualisierung epigenetischer Modifikationen

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2025

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Dynamic changes of the epigenome at specific gene loci, including alterations of chemical modifications on the DNA or histone proteins, are critical in development and disease. Bimolecular Anchor Detector (BiAD) sensors can be used to visualize these modifications in living cells with locus resolution. Recently, we improved the BiAD technology by enhancing the sensor sensitivity and expanded the range of detectable modifications, enabling a broad application of the BiAD sensors in various contexts.

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