The Lipase Engineering Database – a navigation and analysis tool for protein families

Fischer, Markus; Pleiss, Jürgen

The Lipase Engineering Database – a navigation and analysis tool for protein families

dc.contributor.author	Fischer, Markus	de
dc.contributor.author	Pleiss, Jürgen	de
dc.date.accessioned	2006-06-02	de
dc.date.accessioned	2016-03-31T07:46:45Z
dc.date.available	2006-06-02	de
dc.date.available	2016-03-31T07:46:45Z
dc.date.issued	2003	de
dc.date.updated	2015-12-11	de
dc.description.abstract	The Lipase Engineering Database (http://www.led.uni-stuttgart.de) integrates information on sequence, structure, and function of lipases, esterases, and related proteins. Sequence data on 806 protein entries are assigned to 38 homologous families, which are grouped into 16 superfamilies with no global sequence similarity between each other. For each family, multisequence alignments are provided with functionally relevant residues annotated. Pre-calculated phylogenetic trees allow navigation inside superfamilies. Experimental structures of 45 proteins are superposed and consistently annotated. The Lipase Engineering Database has been applied to systematically analyze sequence-structure-function relationships of this vast and diverse enzyme class. It is a useful tool to identify functionally relevant residues apart from the active site residues, and to design mutants with desired substrate specificity.	en
dc.identifier.other	26255027X	de
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-26789	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/851
dc.identifier.uri	http://dx.doi.org/10.18419/opus-834
dc.language.iso	en	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.subject.classification	Bioinformatik , Molekulare Bioinformatik , Proteindesign , Alignment <Biochemie>	de
dc.subject.ddc	540	de
dc.subject.other	integrated database , sequence-structure-function relationship , relational database , sequence alignment , phylogenetic analysis	en
dc.title	The Lipase Engineering Database – a navigation and analysis tool for protein families	en
dc.type	preprint	de
ubs.fakultaet	Fakultät Chemie	de
ubs.institut	Institut für Technische Biochemie	de
ubs.opusid	2678	de
ubs.publikation.source	Nucleic acids research 31 (2003), S. 319-321. URL http://dx.doi.org/10.1093/nar/gkg015	de
ubs.publikation.typ	Preprint	de

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