Lipase-catalyzed resolution of racemic 2-aklyl substituted 1-alkanols
| dc.contributor.author | Barth, Stefan | de |
| dc.contributor.author | Effenberger, Franz | de |
| dc.date.accessioned | 2009-08-28 | de |
| dc.date.accessioned | 2016-03-31T07:47:48Z | |
| dc.date.available | 2009-08-28 | de |
| dc.date.available | 2016-03-31T07:47:48Z | |
| dc.date.issued | 1993 | de |
| dc.description.abstract | (R)-2-alkyl-1-alkanoids (R)-1 with high optical purities were obtained by lipase-catalyzed esterification of the racemic substrates (R,S)-1 with vinyl acetate in dichloromethane. The alcohols (R)-1 were oxidized without racemization to the corresponding carboxylic acids (R)-4. The enriched (S)-acetates (S)-3 either were saponified to the alcohols (S)-1 which are substrates for a second lipase-catalyzed transesterification to give (S)-1 in high optical purity or were racemized and applied once again in the kinetic resolution to prepare (R)-1. | en |
| dc.identifier.other | 316226270 | de |
| dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-44477 | de |
| dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/1183 | |
| dc.identifier.uri | http://dx.doi.org/10.18419/opus-1166 | |
| dc.language.iso | en | de |
| dc.rights | info:eu-repo/semantics/openAccess | de |
| dc.subject.classification | Alkanole , Enzymkatalyse , Racemisierung | de |
| dc.subject.ddc | 540 | de |
| dc.title | Lipase-catalyzed resolution of racemic 2-aklyl substituted 1-alkanols | en |
| dc.type | article | de |
| ubs.fakultaet | Fakultät Chemie | de |
| ubs.institut | Institut für Organische Chemie | de |
| ubs.opusid | 4447 | de |
| ubs.publikation.source | Tetrahedron / Asymmetry 4 (1993), S. 823-833. URL http://dx.doi.org./10.1016/S0957-4166(00)80120-2 | de |
| ubs.publikation.typ | Zeitschriftenartikel | de |