Retinoic acid modulates gap junctional permeability: a comparative study of dye spreading and ionic coupling in cultured cells

Brümmer, Franz; Zempel, Günther; Bühle, Peter; Stein, Johannes-Christoph; Hülser, Dieter F.

Retinoic acid modulates gap junctional permeability: a comparative study of dye spreading and ionic coupling in cultured cells

dc.contributor.author	Brümmer, Franz	de
dc.contributor.author	Zempel, Günther	de
dc.contributor.author	Bühle, Peter	de
dc.contributor.author	Stein, Johannes-Christoph	de
dc.contributor.author	Hülser, Dieter F.	de
dc.date.accessioned	2011-11-21	de
dc.date.accessioned	2016-03-31T07:53:02Z
dc.date.available	2011-11-21	de
dc.date.available	2016-03-31T07:53:02Z
dc.date.issued	1991	de
dc.date.updated	2011-11-22	de
dc.description.abstract	All-trans retinoic acid (RA), which was recently identified as a morphogen, affects gap junctional permeability in a dose- and time-dependent manner. In five different established mammalian cell lines (FL, BRL, BICR/M1Rk, HEL37, BT5C1) 100 μmol/liter RA reduced Lucifer yellow spreading within 30 min to 20-50% of the control. Ionic coupling, however, remained almost unaffected under the same conditions. Freezefractured membranes of untreated and RA-treated cells were similar with regard to frequency and sizes of gap junction plaques. With concentrations of less than 10 μmol/liter RA the dye spreading increased significantly in the human amniotic cell line FL, pointing to a possible modulatory effect of RA on junctional communication.	en
dc.identifier.other	363846573	de
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68876	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/1963
dc.identifier.uri	http://dx.doi.org/10.18419/opus-1946
dc.language.iso	en	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.subject.classification	Zellkultur , Gap junction , Retinoide	de
dc.subject.ddc	570	de
dc.title	Retinoic acid modulates gap junctional permeability: a comparative study of dye spreading and ionic coupling in cultured cells	en
dc.type	article	de
ubs.fakultaet	Fakultät Energie-, Verfahrens- und Biotechnik	de
ubs.institut	Institut für Biomaterialien und biomolekulare Systeme	de
ubs.opusid	6887	de
ubs.publikation.source	Experimental cell research 196 (1991), S. 158-163. URL http://dx.doi.org./10.1016/0014-4827(91)90245-P	de
ubs.publikation.typ	Zeitschriftenartikel	de

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