Application of cyclic diaryliodonium salts in the synthesis of axially chiral natural product analogues

Klischan, Moritz K. T.; David, Céline; Grudzinski, Daniel; Frey, Wolfgang; Stork, Björn; Pietruszka, Jörg

Application of cyclic diaryliodonium salts in the synthesis of axially chiral natural product analogues

dc.contributor.author	Klischan, Moritz K. T.
dc.contributor.author	David, Céline
dc.contributor.author	Grudzinski, Daniel
dc.contributor.author	Frey, Wolfgang
dc.contributor.author	Stork, Björn
dc.contributor.author	Pietruszka, Jörg
dc.date.accessioned	2024-07-05T12:02:28Z
dc.date.available	2024-07-05T12:02:28Z
dc.date.issued	2024	de
dc.date.updated	2024-07-02T03:10:06Z
dc.description.abstract	The application of cyclic diaryliodonium salts in the synthesis of bioactive natural product analogues was demonstrated. Axially chiral biaryls were obtained via the enantioselective ring opening of cyclic diaryliodonium salts. Regioselective borylation was key in accessing both enantiomers of a biphenol key intermediate in eight steps overall. 8,8″-Amino biflavones were synthesized, their bioactivity profiled, and the eutomer identified. The structure-activity relationship was probed.	en
dc.description.sponsorship	Deutsche Forschungsgemeinschaft	de
dc.description.sponsorship	Forschungszentrum Jülich	de
dc.description.sponsorship	Heinrich-Heine-Universität Düsseldorf	de
dc.identifier.issn	1523-7052
dc.identifier.issn	1523-7060
dc.identifier.other	1894714490
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-146106	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/14610
dc.identifier.uri	http://dx.doi.org/10.18419/opus-14591
dc.language.iso	en	de
dc.relation.uri	doi:10.1021/acs.orglett.4c01308	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	de
dc.subject.ddc	540	de
dc.title	Application of cyclic diaryliodonium salts in the synthesis of axially chiral natural product analogues	en
dc.type	article	de
ubs.fakultaet	Chemie	de
ubs.institut	Institut für Organische Chemie	de
ubs.publikation.seiten	5258-5262	de
ubs.publikation.source	Organic letters 26 (2024), S. 5258-5262	de
ubs.publikation.typ	Zeitschriftenartikel	de

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