The AMPA antagonist GYKI 52466 reverses the anticataleptic effects of the competitive NMDA antagonist CGP 37849

Hauber, Wolfgang; Waldenmeier, Marc T.

The AMPA antagonist GYKI 52466 reverses the anticataleptic effects of the competitive NMDA antagonist CGP 37849

dc.contributor.author	Hauber, Wolfgang	de
dc.contributor.author	Waldenmeier, Marc T.	de
dc.date.accessioned	2009-03-31	de
dc.date.accessioned	2016-03-31T07:52:22Z
dc.date.available	2009-03-31	de
dc.date.available	2016-03-31T07:52:22Z
dc.date.issued	1994	de
dc.date.updated	2013-04-24	de
dc.description.abstract	The effects of the AMPA receptor antagonist GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine HCl) on haloperidol-induced catalepsy were tested in drug-naive rats and in rats pretreated with the competitive NMDA receptor antagonist CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid). CGP 37849 (4 mg/kg i.p.) given alone significantly reversed haloperidol-induced catalepsy (0.5 mg/kg i.p.) while GYKI 52466 (4.8 mg/kg i.p.) given alone was without effect. Administration of GYKI 52466 to rats pretreated with CGP 37849 abolished the anticataleptic effects of the competitive NMDA receptor antagonist seen following single administration. Thus the AMPA receptor antagonist prevents behavioural effects induced by a NMDA receptor antagonist in this behavioral model.	en
dc.identifier.other	314171657	de
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39646	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/1811
dc.identifier.uri	http://dx.doi.org/10.18419/opus-1794
dc.language.iso	en	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.subject.classification	Katalepsie , NMDA-Rezeptor	de
dc.subject.ddc	570	de
dc.subject.other	AMPA receptor , NMDA receptor , Rat	en
dc.title	The AMPA antagonist GYKI 52466 reverses the anticataleptic effects of the competitive NMDA antagonist CGP 37849	en
dc.type	article	de
ubs.fakultaet	Fakultät Energie-, Verfahrens- und Biotechnik	de
ubs.institut	Institut für Biomaterialien und biomolekulare Systeme	de
ubs.opusid	3964	de
ubs.publikation.source	European Journal of Pharmacology 256 (1994), S. 339-342. URL http://dx.doi.org./10.1016/0014-2999(94)90561-4	de
ubs.publikation.typ	Zeitschriftenartikel	de

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