The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine

Hauber, Wolfgang; Andersen, Ragna

The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine

dc.contributor.author	Hauber, Wolfgang	de
dc.contributor.author	Andersen, Ragna	de
dc.date.accessioned	2009-04-03	de
dc.date.accessioned	2016-03-31T07:52:22Z
dc.date.available	2009-04-03	de
dc.date.available	2016-03-31T07:52:22Z
dc.date.issued	1993	de
dc.date.updated	2013-05-27	de
dc.description.abstract	The effects of the non-NMDA glutamate receptor antagonist GYKI 52466 (2.4 and 4.8 mg/kg, i.p.) on spontaneous locomotor activity and haloperidol-induced catalepsy (0.5 mg/kg, i.p.) were assessed in naive rats and in rats pretreated with the NMDA antagonist dizocilpine (0.08 mg/kg, i.p.). GYKI 52466 given alone did not alter locomotor activity and haloperidol-induced catalepsy, but significantly antagonized the dizocilpine-induced locomotor stimulation and counteracted the anti-cataleptic effects of dizocilpine on haloperidol-induced catalepsy. Thus blockade of non-NMDA glutamate receptors antagonized the behavioural stimulant effects of a NMDA receptor blockade.	en
dc.identifier.other	31417687X	de
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39746	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/1815
dc.identifier.uri	http://dx.doi.org/10.18419/opus-1798
dc.language.iso	en	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.subject.classification	NMDA-Rezeptor , Ratte , Katalepsie	de
dc.subject.ddc	570	de
dc.subject.other	NMDA receptors , Non-NMDA receptors , Dizocilpine , GYKI 52466 , Locomotion , Haloperido , induced catalepsy , Rat	en
dc.title	The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine	en
dc.type	article	de
ubs.fakultaet	Fakultät Energie-, Verfahrens- und Biotechnik	de
ubs.institut	Institut für Biomaterialien und biomolekulare Systeme	de
ubs.opusid	3974	de
ubs.publikation.source	Naunyn-Schmiedeberg's Archives of Pharmacology 348 (1993), S. 486-490. URL http://dx.doi.org./10.1007/BF00173207	de
ubs.publikation.typ	Zeitschriftenartikel	de

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