Browsing by Author "Hörsch, Brigitte"
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Item Open Access Ein einfacher Zugang zu (R)-α-Hydroxycarbonsäuren und (R)-1-Amino-2-alkoholen aus (R)-Cyanhydrinen(1990) Ziegler, Thomas; Hörsch, Brigitte; Effenberger, FranzIn der vorliegenden Arbeit wird die Hydrolyse und die Hydrierung von (R)-Cyanhydrinen zu α-Hydroxycarbonsäuren (R)-3 und 1- Amino-2-alkoholen (R)-6 beschrieben.Item Open Access Enzyme-catalyzed synthesis of (R)-ketone-cyanohydrins and their hydrolysis to (R)-α-hydroxy-α-methyl-carboxylic acids(1991) Effenberger, Franz; Hörsch, Brigitte; Weingart, Franz; Ziegler, Thomas; Kühner, Stefan(R)-Ketone-cyanohydrins (R)-2 are obtained with high enantioselectivity from aliphatic ketones 1 and HCN in organic solvents using (R)-oxynitrilase (EC 4.1.2.10) as catalyst. Acid catalyzed hydrolysis of the cyanohydrins (R)-2 affords the corresponding (R)-α-hydroxy-α-methyl-carboxylic acids (R)-3 without measurable racemization.Item Open Access Enzyme-catalyzed synthesis of (S)-cyanohydrins and subsequent hydrolysis to (S)-α-hydroxy-carboxylic acids(1990) Effenberger, Franz; Hörsch, Brigitte; Förster, Siegfried; Ziegler, Thomas(S)-Cyanohydrins 2 are obtained with high enantioselectivity from aromatic aldehydes and HCN in the presence of (S)-oxynitrilase (E.C.4.1.2.11). Acid-catalyzed hydrolysis of the cyanohydrins 2 affords the corresponding (S)-α-hydroxy carboxylic acids 3 without racemization.