15 Fakultätsübergreifend / Sonstige Einrichtung
Permanent URI for this collectionhttps://elib.uni-stuttgart.de/handle/11682/16
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Item Open Access Development of individual insulin infusion profiles for open loop infusion systems(1984) Strack, Thomas; Krause, Ulrich; Schulz, Gerhard; Beyer, Jürgen; Beutelspacher, Friedrich; Nagel, Joachim H.The computer program for the open loop infusion device simulated the feed-back structure of a closed loop insulin secretion control by an algorithm based upon a theoretical postprandial blood sugar profile. Fifteen unstable juvenile onset insulin requiring diabetics could be well controlled after two to three days of an intravenous open loop insulin infusion program. The programs consisted of two constant basal rates and superimposed wavy step profile programs activated at the beginning of each meal.The preabsorptive bolus or cephalic phase was an additional tool both for improved postprandial blood sugar control and further reduction of insulin consumption.The programmable insulin infusion device proved as a valuable tool for the study of a sophisticated insulin infusion profile suitable as well for open loop as for closed loop insulin infusion systems.Item Open Access Development and application of insulin infusion profiles for therapy of type I diabetics with portable insulin infusion systems(1984) Schulz, Gerhard; Strack, Thomas; Beyer, Jürgen; Krause, Ulrich; Cordes, Uwe; Weber, Thomas; Nagel, Joachim H.; Beutelspacher, FriedrichThe metabolism of insuIin-dependent diabetics (lDDs) cannot always be normalized by the conventional subcutaneous insulin regimen that usually provides only two Injections of reguIar and intermediate-acting insulin per day, but glucose-controlled intravenous insuIin infusion ensures almost normal glycaemia all day long. However, glucose-controlled insulin infusion systems (GCIIS) are available only for inpatient treatment because, at present, in vivo glucose measuring systems are not suitable for portable devices. Thus only open-loop devices are considered for outpatient treatment for brittle IDDs. There is no difficulty in findIng the right dosage for the basic insulin requirement, but control of the postprandial blood glucose increase presents a greater problem since the preprandial blood glucose level should be restored within two hours postprandially, without rlsking severe hypo- or hyperglycaemia. It Is obvious that insulin dosage alone is insufficient for this, but the timing of the insulin infusion may be important. The aim of this study was to clarify the importance of different insulin infusion profiles on daily and postprandial blood glucose levels.Item Open Access Die Entwicklung von Insulininfusionsprofilen zur Therapie insulinpflichtiger Diabetiker mit tragbaren Insulininfusionssystemen(1982) Schulz, Gerhard; Beyer, Jürgen; Strack, Thomas; Krause, Ulrich; Nagel, Joachim H.; Cordes, Uwe; Weber, ThomasWir analysieren den Insulinbedarf von 7 insulinpflichtigen Diabetikem am glukosekontrollierten Insulininfusionssystem und übertrugen die dabei gewonnenen Daten auf ein portables Insulininfusionsgerät, bei dem individuell Insulinabgabeproflle programmiert werden können, bzw. ein System mit einfachen Rechteckprofllen. Unsere Untersuchungen ergaben, daß mit individuell erstellten Insulininfusionsprofilen eine bessere Glättung der Blutzuckerspiegel zu erreichen ist. Bei Berücksichtigung der kephalen Phase der Insulinsekretion kann offenbar sogar Insulin eingespart werden.Item Open Access The insulin requirement of insulin dependent diabetics applying different open loop insulin infusion systems(1981) Schulz, Gerhard; Beyer, Jürgen; Strack, Thomas; Krause, Ulrich; Nagel, Joachim H.-