06 Fakultät Luft- und Raumfahrttechnik und Geodäsie
Permanent URI for this collectionhttps://elib.uni-stuttgart.de/handle/11682/7
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Item Open Access Multiscale and multiphase modeling and numerical simulation of function-perfusion processes in the liver(Stuttgart : Institut für Statik und Dynamik der Luft und Raumfahrtkonstruktionen, Universität Stuttgart, 2023) Lambers, Lena; Ricken, Tim (Prof. Dr.-Ing.)Item Open Access Modeling freezing and BioGeoChemical processes in Antarctic sea ice(2024) Pathak, Raghav; Seyedpour, Seyed Morteza; Kutschan, Bernd; Thom, Andrea; Thoms, Silke; Ricken, TimThe Antarctic sea ice, which undergoes annual freezing and melting, plays a significant role in the global climate cycle. Since satellite observations in the Antarctic region began, 2023 saw a historically unprecedented decrease in the extent of sea ice. Further ocean warming and future environmental conditions in the Southern Ocean will influence the extent and amount of ice in the Marginal Ice Zones (MIZ), the BioGeoChemical (BGC) cycles, and their interconnected relationships. The so‐called pancake floes are a composition of a porous sea ice matrix with interstitial brine, nutrients, and biological communities inside the pores. The ice formation and salinity are both dependent on the ambient temperature. To realistically model these multiphasic and multicomponent coupled processes, the extended Theory of Porous Media (eTPM) is used to develop Partial Differential Equations (PDEs) based high‐fidelity models capable of simulating the different seasonal variations in the region. All critical variables like salinity, ice volume fraction, and temperature, among others, are considered and have their equations of state. The phase transition phenomenon is approached through a micro‐macro linking scheme. In this paper, a phase‐field solidification model [4] coupled with salinity is used to model the microscale freezing processes and up‐scaled to the macroscale eTPM model. The evolution equations for the phase field model are derived following Landau‐Ginzburg order parameter gradient dynamics and mass conservation of salt allowing to model the salt trapped inside the pores. A BGC flux model for sea ice is set up to simulate the algal species present in the sea ice matrix. Ordinary differential equations (ODE) are employed to represent the diverse environmental factors involved in the growth and loss of distinct BGC components. Processes like photosynthesis are dependent on temperature and salinity, which are derived through an ODE‐PDE coupling with the eTPM model. Academic simulations and results are presented as validation for the mathematical model. These high‐fidelity models eventually lead to their incorporation into large‐scale global climate models.Item Open Access Simulation of contaminant transport through the vadose zone : a continuum mechanical approach within the framework of the extended Theory of Porous Media (eTPM)(2023) Seyedpour, S. M.; Thom, A.; Ricken, T.The simulation of contaminant transport through the vadose zone enjoys high significance for decision makers and contaminated site planners since the vadose zone can serve as a filter, but many contaminants can be transported from this region to aquifers. The intention of this paper is to utilize the extended Theory of Porous Media (eTPM) to develop a ternary model for the simulation of contaminant transport in the vadose zone whose application is subsequently shown via a numerical example. The simulation was conducted for 140 days, during which the contamination source was removed after 25 days. The results indicate that the contaminant reached the water table after 76 days. The concentration of the contaminant reaching the groundwater was 17% less than that of the contaminant source.Item Open Access Experiments meet simulations : understanding skeletal muscle mechanics to address clinical problems(2024) Ateş, Filiz; Röhrle, OliverThis article aims to present some novel experimental approaches and computational methods providing detailed insights into the mechanical behavior of skeletal muscles relevant to clinical problems associated with managing and treating musculoskeletal diseases. The mechanical characterization of skeletal muscles in vivo is crucial for better understanding of, prevention of, or intervention in movement alterations due to exercise, aging, or pathologies related to neuromuscular diseases. To achieve this, we suggest an intraoperative experimental method including direct measurements of human muscle forces supported by computational methodologies. A set of intraoperative experiments indicated the major role of extracellular matrix (ECM) in spastic cerebral palsy. The force data linked to joint function are invaluable and irreplaceable for evaluating individual muscles however, they are not feasible in many situations. Three‐dimensional, continuum‐mechanical models provide a way to predict the exerted muscle forces. To obtain, however, realistic predictions, it is important to investigate the muscle not by itself, but embedded within the respective musculoskeletal system, for example, a 6‐muscle upper arm model, and the ability to obtain non‐invasively, or at least, minimally invasively material parameters for continuum‐mechanical skeletal muscle models, for example, by presently proposed homogenization methodologies. Botulinum toxin administration as a treatment option for spasticity is exemplified by combining experiments with modeling to find out the mechanical outcomes of altered ECM and the controversial effects of the toxin. The potentials and limitations of both experimental and modeling approaches and how they need each other are discussed.Item Open Access Characterization of muscle weakness due to myasthenia gravis using shear wave elastography(2023) Zimmer, Manuela; Kleiser, Benedict; Marquetand, Justus; Ates, FilizMyasthenia gravis (MG) is often accompanied with muscle weakness; however, little is known about mechanical adaptions of the affected muscles. As the latter can be assessed using ultrasound shear wave elastography (SWE), this study characterizes the biceps brachii muscle of 11 patients with MG and compares them with that of 14 healthy volunteers. Simultaneous SWE, elbow torque and surface electromyography measurements were performed during rest, maximal voluntary contraction (MVC) and submaximal isometric contractions (up to 25%, 50% and 75% MVC) at different elbow angles from flexion to extension. We found that, with increasing elbow angle, maximum elbow torque decreased (p < 0.001), whereas muscle stiffness increased during rest (p = 0.001), MVC (p = 0.004) and submaximal contractions (p < 0.001). Muscle stiffness increased with increasing contraction intensities during submaximal contractions (p < 0.001). In comparison to the healthy cohort, muscle stiffness of MG patients was 2.1 times higher at rest (p < 0.001) but 8.93% lower in active state (75% MVC, p = 0.044). We conclude that (i) increased muscle stiffness shown by SWE during rest might be an indicator of MG, (ii) SWE reflects muscle weakness and (iii) SWE can be used to characterize MG muscle.Item Open Access Transient high-frequency spherical wave propagation in porous medium using fractional calculus technique(2023) Soltani, Kamran; Seyedpour, Seyed Morteza; Ricken, Tim; Rezazadeh, GhaderTransient high-frequency spherical wave propagation in the porous medium is studied using the Biot-JKD theory. The porous media is considered to be a composed of deformable solid skeleton and viscous incompressible fluid inside the pores. In order to treat the fractional proportionality of the dynamic tortuosity to the frequency (or equivalently, to time) due to the viscous interaction between solid and fluid phases, the fractional calculus theory along with the Laplace and Fourier transforms are used to solve the coupled governing partial differential equations of the scaler and vector potential functions obtained from the Helmholtz’s decomposition in the Laplace domain. Both the longitudinal and transverse waves, additionally the reflection and transmission kernels are determined in detail at the Laplace domain. For the Laplace-to-time inversion transform, Durbin’s numerical formula is used and the independence of the results from the involved tuning and accuracy parameters is checked. The effects of the porosity, dynamic tortuosity, characteristics length, etc. on the reflected pressure and stress are investigated. The general pattern of the results is similar to our previous knowledge of wave propagation. Further works and experiments may be conducted in future works for various applications.Item Open Access How mechanics of individual muscle-tendon units define knee and ankle joint function in health and cerebral palsy : a narrative review(2023) Kaya Keles, Cemre Su; Ates, FilizThis study reviews the relationship between muscle-tendon biomechanics and joint function, with a particular focus on how cerebral palsy (CP) affects this relationship. In healthy individuals, muscle size is a critical determinant of strength, with muscle volume, cross-sectional area, and moment arm correlating with knee and ankle joint torque for different isometric/isokinetic contractions. However, in CP, impaired muscle growth contributes to joint pathophysiology even though only a limited number of studies have investigated the impact of deficits in muscle size on pathological joint function. As muscles are the primary factors determining joint torque, in this review two main approaches used for muscle force quantification are discussed. The direct quantification of individual muscle forces from their relevant tendons through intraoperative approaches holds a high potential for characterizing healthy and diseased muscles but poses challenges due to the invasive nature of the technique. On the other hand, musculoskeletal models, using an inverse dynamic approach, can predict muscle forces, but rely on several assumptions and have inherent limitations. Neither technique has become established in routine clinical practice. Nevertheless, identifying the relative contribution of each muscle to the overall joint moment would be key for diagnosis and formulating efficient treatment strategies for patients with CP. This review emphasizes the necessity of implementing the intraoperative approach into general surgical practice, particularly for joint correction operations in diverse patient groups. Obtaining in vivo data directly would enhance musculoskeletal models, providing more accurate force estimations. This integrated approach can improve the clinicians’ decision-making process and advance treatment strategies by predicting changes at the muscle and joint levels before interventions, thus, holding the potential to significantly enhance clinical outcomes.Item Open Access Quantifying the effects of achilles tendon lengthening surgery : an intraoperative approach(2023) Brendecke, Elena; Tsitlakidis, Stefanos; Götze, Marco; Hagmann, Sébastien; Ates, FilizAchilles tendon lengthening (ATL) is frequently used in the treatment of foot deformities. However, there is currently no objective method to determine the optimal muscle length during surgery. We developed an intraoperative approach to evaluate the passive and active forces of the triceps surae muscle group before and after ATL and aimed to test the following hypotheses: 1) the ankle passive range of motion (ROM) increases, 2) passive muscle forces decrease post-ATL, and 3) forces measured from patients with non-neurological and neurological conditions demonstrate different characteristics. Passive forces at various ankle joint positions were measured in ten patients (11.3 ± 3.0 years old) pre- and post-ATL using a force transducer attached to the Achilles tendon. In six patients, active isometric forces were measured by stimulating the triceps surae supramaximally. Passive forces decreased by 94.3% (p < 0.0001), and ROM increased by 89.4% (p < 0.0001) post-ATL. The pre-ATL passive forces were 70.8% ± 15.1% lower in patients with idiopathic foot deformities than in patients with neurological conditions (p < 0.001). The peak active force of 209.8 ± 114.3 N was achieved at an ankle angle of 38.3° ± 16.0°, where the passive force was 6.3 ± 6.7 N. The inter-individual variability was substantial in both groups. In conclusion, the hypotheses posed were supported. The present findings suggest that muscle passive and active force production as well as the inter-individual variability should be considered when planning further treatment.Item Open Access In vivo assessment of shear wave propagation in pennate muscles using an automatic ultrasound probe alignment system(2023) Zimmer, Manuela; Bunz, Elsa K.; Ehring, Tobias; Kaiser, Benedikt; Kienzlen, Annika; Schlüter, Henning; Zürn, ManuelItem Open Access On effects of freezing and thawing cycles of concrete containing nano-SiO2 : experimental study of material properties and crack simulation(2023) Arasteh-Khoshbin, O.; Seyedpour, S. M.; Brodbeck, M.; Lambers, L.; Ricken, T.Construction during cold weather can lead to freezing accidents in concrete, causing significant hidden threats to the project’s performance and safety by affecting the mechanical properties and durability reduction. This study aims to deduce the compressive strength and durability of the concrete containing nano- SiO2under freezing-thawing cycles with the Caspian seawater curing condition. The specimens were subjected to freezing-thawing cycles according to ASTM C666. Furthermore, crack propagation in the concrete after freezing-thawing cycles is simulated. The results reveal that adding until nano- SiO2until 6% improved compressive strength before and after freezing-thaw cycles. The water permeability experiences a substantial reduction as the amount of nano- SiO2increases. Furthermore, the water permeability exhibits a positive correlation with the number of cycles, resulting in significantly higher values after 150 cycles compared to the initial sample. Moreover, adding 8% nano- SiO2reduced the depth of water permeability and chloride ion penetration after 150 cycles by 57% and 86%, respectively. The crack simulation results indicate that concrete containing 6% nano- SiO2shows an optimal resistance against crack formation. Concrete with 6% nano- SiO2requires 13.88% less force for crack initialization after 150 freezing and thawing cycles. Among different nano- SiO2percentages, 6% shows the best crack resistance and 8% the minimum water permeability and chloride ion penetration.