11 Interfakultäre Einrichtungen

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    ItemOpen Access
    A unified research data infrastructure for catalysis research : challenges and concepts
    (2021) Wulf, Christoph; Beller, Matthias; Boenisch, Thomas; Deutschmann, Olaf; Hanf, Schirin; Kockmann, Norbert; Kraehnert, Ralph; Oezaslan, Mehtap; Palkovits, Stefan; Schimmler, Sonja; Schunk, Stephan A.; Wagemann, Kurt; Linke, David
    Modern research methods produce large amounts of scientifically valuable data. Tools to process and analyze such data have advanced rapidly. Yet, access to large amounts of high‐quality data remains limited in many fields, including catalysis research. Implementing the concept of FAIR data (Findable, Accessible, Interoperable, Reusable) in the catalysis community would improve this situation dramatically. The German NFDI initiative (National Research Data Infrastructure) aims to create a unique research data infrastructure covering all scientific disciplines. One of the consortia, NFDI4Cat, proposes a concept that serves all aspects and fields of catalysis research. We present a perspective on the challenging path ahead. Starting out from the current state, research needs are identified. A vision for a integrating all research data along the catalysis value chain, from molecule to chemical process, is developed. Respective core development topics are discussed, including ontologies, metadata, required infrastructure, IP, and the embedding into research community. This Concept paper aims to inspire not only researchers in the catalysis field, but to spark similar efforts also in other disciplines and on an international level.
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    ItemOpen Access
    Association between vitamin D status and eryptosis : results from the German National Cohort study
    (2023) Ewendt, Franz; Schmitt, Marvin; Kluttig, Alexander; Kühn, Julia; Hirche, Frank; Kraus, Frank B.; Ludwig-Kraus, Beatrice; Mikolajczyk, Rafael; Wätjen, Wim; Bürkner, Paul-Christian; Föller, Michael; Stangl, Gabriele I.
    Vitamin D, besides its classical effect on mineral homeostasis and bone remodeling, can also modulate apoptosis. A special form of apoptosis termed eryptosis appears in erythrocytes. Eryptosis is characterized by cell shrinkage, membrane blebbing, and cell membrane phospholipid disorganization and associated with diseases such as sepsis, malaria or iron deficiency, and impaired microcirculation. To our knowledge, this is the first study that linked vitamin D with eryptosis in humans. This exploratory cross-sectional trial investigated the association between the vitamin D status assessed by the concentration of plasma 25-hydroxyvitamin D (25(OH)D) and eryptosis. Plasma 25(OH)D was analyzed by LC-MS/MS, and eryptosis was estimated from annexin V-FITC-binding erythrocytes by FACS analysis in 2074 blood samples from participants of the German National Cohort Study. We observed a weak but clear correlation between low vitamin D status and increased eryptosis ( r  =  − 0.15; 95% CI [− 0.19, − 0.10]). There were no differences in plasma concentrations of 25(OH)D and eryptosis between male and female subjects. This finding raises questions of the importance of vitamin D status for eryptosis in terms of increased risk for anemia or cardiovascular events.
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    ItemOpen Access
    A wealth of P-T-t information from metasediments in the HP-UHP terrane of the Pohorje Mountains, Slovenia, elucidates the evolution of the Eastern Alps
    (2023) Li, Botao; Massonne, Hans‐Joachim; Yuan, Xiaoping
    Contrasting views exist in regard of the evolution of metamorphic rocks in the southeastern Pohorje Mountains (Mts), located in the southeastern Eastern Alps. Major debated points are whether micaschists have experienced ultrahigh‐pressure metamorphism in the Late Cretaceous (Eo‐Alpine) and whether they were continuously exhumed or experienced a multiple subduction-exhumation process from that time on. Therefore, we studied micaschist sample 18Slo39 with two generations of garnet and phengitic muscovite from this area. Our detailed study of this rock included petrographic observations, chemical analyses of minerals with the electron microprobe, pseudosection modelling, conventional geothermometry, and monazite in‐situ U‐Th‐Pb dating using laser‐ablation inductively coupled plasma (ICP) mass spectrometry. The following results were obtained: The studied micaschist was subject to a peak pressure of 1.31 ± 0.14 GPa at 603 ± 26°C in Eo‐Alpine times: 90.62 ± 2.78 (2σ) Ma (Stage I). Contact metamorphism at pressure-temperature conditions of 0.66 ± 0.10 GPa and 577 ± 23°C was induced by the intrusion of the Pohorje pluton (Stage III). We determined an early Miocene age of 18.33 ± 0.43 (2σ) Ma for this intrusion. Based on this study and the previously reported data for a micaschist (16Slo12) taken in the vicinity of sample 18Slo39, a geodynamic model is proposed for the region of the Pohorje Mts considering Eo‐Alpine subduction of oceanic crust and European continental crust, of which the micaschist was part of. Another high‐pressure event in the Eocene (Stage II) was the result of intracontinental subduction because of transpression by the Periadriatic fault system that separates the Eastern Alps from the Southern Alps. This type of subduction gave rise to magma generation and ascent to form the Pohorje pluton, which caused contact metamorphism in its vicinity.
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    ItemOpen Access
    Anti-Zeno purification of spin baths by quantum probe measurements
    (2022) Dasari, Durga Bhaktavatsala Rao; Yang, Sen; Chakrabarti, Arnab; Finkler, Amit; Kurizki, Gershon; Wrachtrup, Jörg
    The quantum Zeno and anti-Zeno paradigms have thus far addressed the evolution control of a quantum system coupled to an immutable bath via non-selective measurements performed at appropriate intervals. We fundamentally modify these paradigms by introducing, theoretically and experimentally, the concept of controlling the bath state via selective measurements of the system (a qubit). We show that at intervals corresponding to the anti-Zeno regime of the system-bath exchange, a sequence of measurements has strongly correlated outcomes. These correlations can dramatically enhance the bath-state purity and yield a low-entropy steady state of the bath. The purified bath state persists long after the measurements are completed. Such purification enables the exploitation of spin baths as long-lived quantum memories or as quantum-enhanced sensors. The experiment involved a repeatedly probed defect center dephased by a nuclear spin bath in a diamond at low-temperature.