11 Interfakultäre Einrichtungen

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    Daily emotion regulation in major depression and borderline personality disorder
    (2023) Zetsche, Ulrike; Bürkner, Paul-Christian; Bohländer, Julian; Renneberg, Babette; Roepke, Stefan; Schulze, Lars
    Emotional disturbances are an inherent aspect of most mental disorders and possibly driven by impaired emotion regulation. In the present study, we examined how exactly affected individuals differ from healthy individuals in regulating their emotions and whether individuals suffering from different mental disorders face similar or distinct difficulty in emotion regulation. We overcome earlier methodological constraints by using a 7-day experience sampling assessing the employment and effectiveness of six regulation strategies real time in 55 individuals with current major depressive disorder, 52 individuals with borderline personality disorder (BPD), and 55 healthy individuals. All participants were female. Both clinical groups employed rumination and suppression more often and acceptance less often than healthy individuals. Depressed individuals ruminated even more often than individuals with BPD. Expressive suppression and rumination showed negative effects on subsequent emotions in all groups. Remarkably, both clinical groups were able to benefit from adaptive regulation strategies if they did select them.
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    Integrating a dynamic central metabolism model of cancer cells with a hybrid 3D multiscale model for vascular hepatocellular carcinoma growth
    (2022) Lapin, Alexey; Perfahl, Holger; Jain, Harsh Vardhan; Reuss, Matthias
    We develop here a novel modelling approach with the aim of closing the conceptual gap between tumour-level metabolic processes and the metabolic processes occurring in individual cancer cells. In particular, the metabolism in hepatocellular carcinoma derived cell lines (HEPG2 cells) has been well characterized but implementations of multiscale models integrating this known metabolism have not been previously reported. We therefore extend a previously published multiscale model of vascular tumour growth, and integrate it with an experimentally verified network of central metabolism in HEPG2 cells. This resultant combined model links spatially heterogeneous vascular tumour growth with known metabolic networks within tumour cells and accounts for blood flow, angiogenesis, vascular remodelling and nutrient/growth factor transport within a growing tumour, as well as the movement of, and interactions between normal and cancer cells. Model simulations report for the first time, predictions of spatially resolved time courses of core metabolites in HEPG2 cells. These simulations can be performed at a sufficient scale to incorporate clinically relevant features of different tumour systems using reasonable computational resources. Our results predict larger than expected temporal and spatial heterogeneity in the intracellular concentrations of glucose, oxygen, lactate pyruvate, f16bp and Acetyl-CoA. The integrated multiscale model developed here provides an ideal quantitative framework in which to study the relationship between dosage, timing, and scheduling of anti-neoplastic agents and the physiological effects of tumour metabolism at the cellular level. Such models, therefore, have the potential to inform treatment decisions when drug response is dependent on the metabolic state of individual cancer cells.
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    Assessing the immediate effects of detached mindfulness on repetitive negative thinking and affect in daily life : a randomized controlled trial
    (2024) Bolzenkötter, Teresa; Bürkner, Paul-Christian; Zetsche, Ulrike; Schulze, Lars
    Objectives. Repetitive negative thinking (RNT) is a problematic thinking style that is related to multiple mental disorders. Detached mindfulness is a technique of metacognitive therapy that aims to reduce RNT. Our study set out to investigate the immediate effects of detached mindfulness in daily life. Methods. Participants with elevated trait RNT ( n = 50) were prompted to engage in detached mindfulness exercises three times a day for 5 consecutive days. Immediate effects on RNT and affect were assessed 15 and 30 min after each exercise using experience sampling methodology. We compared the effects of this exercise phase to (1) a 5-day non-exercise baseline phase and (2) a different group of participants that engaged in an active control exercise ( n = 50). Results. Results of Bayesian multilevel models showed that, across groups, improvements in RNT, negative affect, and positive affect were stronger during the exercise phase than during the non-exercise baseline phase (RNT after 15 min: b = -0.26, 95% CI = [-0.38, -0.14]). However, the two exercise groups did not differ in these improvements (RNT after 15 min: b = 0.02, 95% CI = [-0.22, 0.27]). Thus, the detached mindfulness and the active control exercises resulted in similar effects on RNT and affect in daily life. Conclusions. Results of this study imply that there was no additional benefit of having participants observe their thoughts detached and non-judgmentally, compared to excluding these assumed mechanisms of action as done for the active control group. We discuss possible reasons for the non-difference between the groups.
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    Salivary cortisol and alpha-amylase as stress markers to evaluate an individualized music intervention for people with dementia : feasibility and pilot analyses
    (2024) Hillebrand, Mareike Christina; Sindermann, Cornelia; Montag, Christian; Wuttke, Alexandra; Heinzelmann, Rebecca; Haas, Heidrun; Wilz, Gabriele
    Objectives: We investigated salivary biomarkers of stress, more specifically, cortisol and alpha-amylase, to evaluate effects of individualized music listening (IML) in people with dementia.MethodParticipants were N = 64 nursing home residents with dementia (meanage = 83.53 ± 7.71 years, 68.8% female). Participants were randomly assigned to either listening to their favorite music every other day for a period of six weeks (intervention), or standard care (control). Using the Saliva Children`s Swab (SCS), saliva was collected before, after, and 20 min after IML sessions at the beginning and end of the intervention period for the analysis of salivary alpha-amylase and cortisol.
    Results: Using the SCS was feasible in people with dementia. Nevertheless, there was no effect of IML on salivary stress markers.
    Discussion: Although using SCS was feasible, active patient engagement is required. Future studies need to corroborate findings in larger samples.
    Trial registration: German Clinical Trials Register: DRKS00015641, ISRCTN registry: ISRCTN59052178.