02 Fakultät Bau- und Umweltingenieurwissenschaften

Permanent URI for this collectionhttps://elib.uni-stuttgart.de/handle/11682/3

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Institute: search.filters.UBSInstitut.Institut für Statik und Dynamik der Luft- und RaumfahrtkonstruktionenSubject: search.filters.subject.570

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    Patient‐specific simulation of brain tumour growth and regression
    (2023) Suditsch, Marlon; Ricken, Tim; Wagner, Arndt
    The medical relevance of brain tumours is characterised by its locally invasive and destructive growth. With a high mortality rate combined with a short remaining life expectancy, brain tumours are identified as highly malignant. A continuum‐mechanical model for the description of the governing processes of growth and regression is derived in the framework of the Theory of Porous Media (TPM). The model is based on medical multi‐modal magnetic resonance imaging (MRI) scans, which represent the gold standard in diagnosis. The multi‐phase model is described mathematically via strongly coupled partial differential equations. This set of governing equations is transformed into their weak formulation and is solved with the software package FEniCS. A proof‐of‐concept simulation based on one patient geometry and tumour pathology shows the relevant processes of tumour growth and the results are discussed.
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    Analysing the bone cement flow in the injection apparatus during vertebroplasty
    (2023) Trivedi, Zubin; Gehweiler, Dominic; Wychowaniec, Jacek K.; Ricken, Tim; Gueorguiev-Rüegg, Boyko; Wagner, Arndt; Röhrle, Oliver
    Vertebroplasty, a medical procedure for treating vertebral fractures, requires medical practitioners to inject bone cement inside the vertebra using a cannula attached to a syringe. The required injection force must be small enough for the practitioner to apply it by hand while remaining stable for a controlled injection. Several factors could make the injection force unintuitive for the practitioners, one of them being the non‐Newtonian nature of the bone cement. The viscosity of the bone cement varies as it flows through the different parts of the injection apparatus and the porous cancellous interior of the vertebra. Therefore, it is important to study the flow of bone cement through these parts. This work is a preliminary study on the flow of bone cement through the injection apparatus. Firstly, we obtained the rheological parameters for the power law model of bone cement using experiments using standard clinical equipment. These parameters were then used to obtain the shear rate, viscosity, and velocity profiles of the bone cement flow through the cannula. Lastly, an analysis was carried out to understand the influence of various geometrical parameters of the injection apparatus, in which the radius of the cannula was found to be the most influential parameter.