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http://dx.doi.org/10.18419/opus-11143
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Southan, Alexander | - |
dc.contributor.author | Lang, Tina | - |
dc.contributor.author | Schweikert, Michael | - |
dc.contributor.author | Tovar, Günter E. M. | - |
dc.contributor.author | Wege, Christina | - |
dc.contributor.author | Eiben, Sabine | - |
dc.date.accessioned | 2020-11-20T14:09:08Z | - |
dc.date.available | 2020-11-20T14:09:08Z | - |
dc.date.issued | 2018 | de |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-111602 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/11160 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-11143 | - |
dc.description.abstract | Hydrogels are versatile materials, finding applications as adsorbers, supports for biosensors and biocatalysts or as scaffolds for tissue engineering. A frequently used building block for chemically cross-linked hydrogels is poly(ethylene glycol) diacrylate (PEG-DA). However, after curing, PEG-DA hydrogels cannot be functionalized easily. In this contribution, the stiff, rod-like tobacco mosaic virus (TMV) is investigated as a functional additive to PEG-DA hydrogels. TMV consists of more than 2000 identical coat proteins and can therefore present more than 2000 functional sites per TMV available for coupling, and thus has been used as a template or building block for nano-scaled hybrid materials for many years. Here, PEG-DA (Mn = 700 g/mol) hydrogels are combined with a thiol-group presenting TMV mutant (TMVCys). By covalent coupling of TMVCys into the hydrogel matrix via the thiol-Michael reaction, the storage modulus of the hydrogels is increased compared to pure PEG-DA hydrogels and to hydrogels containing wildtype TMV (wt-TMV) which is not coupled covalently into the hydrogel matrix. In contrast, the swelling behaviour of the hydrogels is not altered by TMVCys or wt-TMV. Transmission electron microscopy reveals that the TMV particles are well dispersed in the hydrogels without any large aggregates. These findings give rise to the conclusion that well-defined hydrogels were obtained which offer the possibility to use the incorporated TMV as multivalent carrier templates e.g. for enzymes in future studies. | en |
dc.language.iso | en | de |
dc.relation.uri | doi:10.1039/c7ra10364f | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.subject.ddc | 500 | de |
dc.subject.ddc | 540 | de |
dc.subject.ddc | 570 | de |
dc.title | Covalent incorporation of tobacco mosaic virus increases the stiffness of poly(ethylene glycol) diacrylate hydrogels | en |
dc.type | article | de |
ubs.fakultaet | Energie-, Verfahrens- und Biotechnik | de |
ubs.fakultaet | Externe wissenschaftliche Einrichtungen | de |
ubs.institut | Institut für Biomaterialien und biomolekulare Systeme | de |
ubs.institut | Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie | de |
ubs.institut | Fraunhofer Institut für Grenzflächen- und Bioverfahrenstechnik (IGB) | de |
ubs.publikation.noppn | yes | de |
ubs.publikation.seiten | 4686-4694 | de |
ubs.publikation.source | RSC advances 8 (2018), pp. 4686-4694 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Southan_2018.pdf | Paper | 1,75 MB | Adobe PDF | Öffnen/Anzeigen |
Southan_2018_support.pdf | Supporting information | 600,25 kB | Adobe PDF | Öffnen/Anzeigen |
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