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dc.contributor.authorSouthan, Alexander-
dc.contributor.authorLang, Tina-
dc.contributor.authorSchweikert, Michael-
dc.contributor.authorTovar, Günter E. M.-
dc.contributor.authorWege, Christina-
dc.contributor.authorEiben, Sabine-
dc.description.abstractHydrogels are versatile materials, finding applications as adsorbers, supports for biosensors and biocatalysts or as scaffolds for tissue engineering. A frequently used building block for chemically cross-linked hydrogels is poly(ethylene glycol) diacrylate (PEG-DA). However, after curing, PEG-DA hydrogels cannot be functionalized easily. In this contribution, the stiff, rod-like tobacco mosaic virus (TMV) is investigated as a functional additive to PEG-DA hydrogels. TMV consists of more than 2000 identical coat proteins and can therefore present more than 2000 functional sites per TMV available for coupling, and thus has been used as a template or building block for nano-scaled hybrid materials for many years. Here, PEG-DA (Mn = 700 g/mol) hydrogels are combined with a thiol-group presenting TMV mutant (TMVCys). By covalent coupling of TMVCys into the hydrogel matrix via the thiol-Michael reaction, the storage modulus of the hydrogels is increased compared to pure PEG-DA hydrogels and to hydrogels containing wildtype TMV (wt-TMV) which is not coupled covalently into the hydrogel matrix. In contrast, the swelling behaviour of the hydrogels is not altered by TMVCys or wt-TMV. Transmission electron microscopy reveals that the TMV particles are well dispersed in the hydrogels without any large aggregates. These findings give rise to the conclusion that well-defined hydrogels were obtained which offer the possibility to use the incorporated TMV as multivalent carrier templates e.g. for enzymes in future studies.en
dc.titleCovalent incorporation of tobacco mosaic virus increases the stiffness of poly(ethylene glycol) diacrylate hydrogelsen
ubs.fakultaetEnergie-, Verfahrens- und Biotechnikde
ubs.fakultaetExterne wissenschaftliche Einrichtungende
ubs.institutInstitut für Biomaterialien und biomolekulare Systemede
ubs.institutInstitut für Grenzflächenverfahrenstechnik und Plasmatechnologiede
ubs.institutFraunhofer Institut für Grenzflächen- und Bioverfahrenstechnik (IGB)de
ubs.publikation.sourceRSC advances 8 (2018), pp. 4686-4694de
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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