Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-11143
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dc.contributor.authorSouthan, Alexander-
dc.contributor.authorLang, Tina-
dc.contributor.authorSchweikert, Michael-
dc.contributor.authorTovar, Günter E. M.-
dc.contributor.authorWege, Christina-
dc.contributor.authorEiben, Sabine-
dc.date.accessioned2020-11-20T14:09:08Z-
dc.date.available2020-11-20T14:09:08Z-
dc.date.issued2018de
dc.identifier.issn2046-2069-
dc.identifier.urihttp://elib.uni-stuttgart.de/handle/11682/11160-
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-111602de
dc.identifier.urihttp://dx.doi.org/10.18419/opus-11143-
dc.description.abstractHydrogels are versatile materials, finding applications as adsorbers, supports for biosensors and biocatalysts or as scaffolds for tissue engineering. A frequently used building block for chemically cross-linked hydrogels is poly(ethylene glycol) diacrylate (PEG-DA). However, after curing, PEG-DA hydrogels cannot be functionalized easily. In this contribution, the stiff, rod-like tobacco mosaic virus (TMV) is investigated as a functional additive to PEG-DA hydrogels. TMV consists of more than 2000 identical coat proteins and can therefore present more than 2000 functional sites per TMV available for coupling, and thus has been used as a template or building block for nano-scaled hybrid materials for many years. Here, PEG-DA (Mn = 700 g/mol) hydrogels are combined with a thiol-group presenting TMV mutant (TMVCys). By covalent coupling of TMVCys into the hydrogel matrix via the thiol-Michael reaction, the storage modulus of the hydrogels is increased compared to pure PEG-DA hydrogels and to hydrogels containing wildtype TMV (wt-TMV) which is not coupled covalently into the hydrogel matrix. In contrast, the swelling behaviour of the hydrogels is not altered by TMVCys or wt-TMV. Transmission electron microscopy reveals that the TMV particles are well dispersed in the hydrogels without any large aggregates. These findings give rise to the conclusion that well-defined hydrogels were obtained which offer the possibility to use the incorporated TMV as multivalent carrier templates e.g. for enzymes in future studies.en
dc.language.isoende
dc.relation.uridoi:10.1039/c7ra10364fde
dc.rightsinfo:eu-repo/semantics/openAccessde
dc.subject.ddc500de
dc.subject.ddc540de
dc.subject.ddc570de
dc.titleCovalent incorporation of tobacco mosaic virus increases the stiffness of poly(ethylene glycol) diacrylate hydrogelsen
dc.typearticlede
ubs.fakultaetEnergie-, Verfahrens- und Biotechnikde
ubs.fakultaetExterne wissenschaftliche Einrichtungende
ubs.institutInstitut für Biomaterialien und biomolekulare Systemede
ubs.institutInstitut für Grenzflächenverfahrenstechnik und Plasmatechnologiede
ubs.institutFraunhofer Institut für Grenzflächen- und Bioverfahrenstechnik (IGB)de
ubs.publikation.noppnyesde
ubs.publikation.seiten4686-4694de
ubs.publikation.sourceRSC advances 8 (2018), pp. 4686-4694de
ubs.publikation.typZeitschriftenartikelde
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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