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http://dx.doi.org/10.18419/opus-14100
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Eyberg, Juri | - |
dc.contributor.author | Göhringer, Daniela | - |
dc.contributor.author | Salihovic, Amila | - |
dc.contributor.author | Richert, Clemens | - |
dc.date.accessioned | 2024-03-20T15:33:53Z | - |
dc.date.available | 2024-03-20T15:33:53Z | - |
dc.date.issued | 2022 | de |
dc.identifier.issn | 1099-0690 | - |
dc.identifier.issn | 1434-193X | - |
dc.identifier.other | 1884044824 | - |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-141191 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/14119 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-14100 | - |
dc.description.abstract | Oligonucleotides are indispensable tools in diagnostics, therapeutic applications and molecular biology. The low base pairing strength of thymine with adenine complicates their use. Ethynylpyridone C‐nucleosides are analogs of thymidine that pair more strongly and with improved base selectivity, and sequences containing these analogs show improved target affinity and selectivity, but their routine use is hampered by diminished yields of solid‐phase syntheses with the known building blocks. A partial loss of base protecting groups during the acidic deblocking step of chain extension cycles was identified as the cause of lower yields. Here we report the synthesis of an improved phosphoramidite building block featuring a pivaloyloxymethyl (POM) base protecting group. This building block gives oligonucleotides containing the strongly pairing ethynylmethylpyridone C‐nucleoside in high yield and purity via solid‐phase synthesis. | en |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG) | de |
dc.description.sponsorship | Projekt DEAL | de |
dc.language.iso | en | de |
dc.relation.uri | doi:10.1002/ejoc.202200611 | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | de |
dc.subject.ddc | 540 | de |
dc.title | Acid‐stable nucleobase protection for a strongly pairing pyridone C‐nucleoside suitable for solid‐phase synthesis of oligonucleotides | en |
dc.type | article | de |
dc.date.updated | 2023-11-14T01:27:34Z | - |
ubs.fakultaet | Chemie | de |
ubs.institut | Institut für Organische Chemie | de |
ubs.publikation.seiten | 7 | de |
ubs.publikation.source | European journal of organic chemistry 2022 (2022), No. e202200611 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 03 Fakultät Chemie |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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EJOC_EJOC202200611.pdf | 2,14 MB | Adobe PDF | Öffnen/Anzeigen |
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