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http://dx.doi.org/10.18419/opus-14408
Autor(en): | Damakoudi, Vassiliki Feldner, Tobias Dilji, Edina Belkin, Andrey Richert, Clemens |
Titel: | Hybridization networks of mRNA and branched RNA hybrids |
Erscheinungsdatum: | 2020 |
Dokumentart: | Zeitschriftenartikel |
Seiten: | 924-930 |
Erschienen in: | ChemBioChem 22 (2021), S. 924-930 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-144278 http://elib.uni-stuttgart.de/handle/11682/14427 http://dx.doi.org/10.18419/opus-14408 |
ISSN: | 1439-7633 1439-4227 |
Zusammenfassung: | Messenger RNA (mRNA) is emerging as an attractive biopolymer for therapy and vaccination. To become suitable for vaccination, mRNA is usually converted to a biomaterial, using cationic peptides, polymers or lipids. An alternative form of converting mRNA into a material is demonstrated that uses branched oligoribonucleotide hybrids with the ability to hybridize with one or more regions of the mRNA sequence. Two such hybrids with hexamer arms and adamantane tetraol as branching element were prepared by solution‐phase synthesis. When a rabies mRNA was treated with the branched hybrids at 1 M NaCl concentration, biomaterials formed that contained both of the nucleic acids. These results show that branched oligoribonucleotides are an alternative to the often toxic reagents commonly used to formulate mRNA for medical applications. |
Enthalten in den Sammlungen: | 03 Fakultät Chemie |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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CBIC_CBIC202000678.pdf | 1,88 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons