Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.18419/opus-14440
Autor(en): | Junge, Thorsten Titze, Marvin Frey, Wolfgang Peters, René |
Titel: | Asymmetric hydrocyanation of N‐phosphinoyl aldimines with acetone cyanohydrin by cooperative Lewis acid/onium salt/Brønsted base catalysis |
Erscheinungsdatum: | 2021 |
Dokumentart: | Zeitschriftenartikel |
Seiten: | 1509-1512 |
Erschienen in: | ChemCatChem 13 (2021), S. 1509-1512 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-144593 http://elib.uni-stuttgart.de/handle/11682/14459 http://dx.doi.org/10.18419/opus-14440 |
ISSN: | 1867-3899 1867-3880 |
Zusammenfassung: | α‐Amino acids are of fundamental importance for life. Both natural and artificial α‐amino acids also play a crucial role for pharmaceutical purposes. The catalytic asymmetric Strecker reaction still provides one of the most attractive strategies to prepare scalemic α‐amino acids. Here we disclose a new concept for Strecker reactions, in which an achiral Brønsted base cooperates with a Lewis acid and an aprotic ammonium salt, which are both arranged in the same chiral catalyst entity. The described method could successfully address various long‐standing practical issues of this reaction type. The major practical advantages are that (1) the N‐protecting group is readily removable, (2) acetone cyanohydrin is attractive as cyanation reagent in terms of atom economy and cost efficiency, (3) an excess of the cyanation reagent is not necessary, (4) the new method does not require additives and (5) is performed at ambient temperature. |
Enthalten in den Sammlungen: | 03 Fakultät Chemie |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
CCTC_CCTC202001921.pdf | 931,64 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons