Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-1799
|Title:||Clozapine improves dizocilpine-induced delayed alternation impairment in rats|
|metadata.ubs.publikation.source:||Journal of neural transmission 94 (1993), S. 233-233. URL http://dx.doi.org./10.1007/BF01277027|
|Abstract:||The effects of systemic administration of dizocilpine (0.16mg/kg, i.p.), clozapine (7.5mg/kg, s.c.) and coadministration of dizocilpine (0.16mg/ kg, i.p.) and clozapine (7.5mg/kg, s.c.) on acquisition of delayed alternation in a T-maze were tested in rats (N=7 per group) on six days with 10 choices per day and animal. Clozapine given alone did not impair delayed alternation learnint, except of the first day. Dizocilpine induced a significant delayed alternation impairment on all days tested. Pretreatment with clozapine significantly improved the dizocilpine-induced impairment. Treatment-induced changes of delayed alternation learning and of locomotor activities showed no correlation. The results demonstrate that clozapine functionally compensated for deficits induced by a blockade of the N-methyl-D-asparatate (NMDA) subtype of glutamate receptors.|
|Appears in Collections:||04 Fakultät Energie-, Verfahrens- und Biotechnik|
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